The impact of base excision DNA repair in age-related neurodegenerative diseases

被引：56

作者：

Leandro, Giovana S. ^{[1
,2
]}

Sykora, Peter ^{[1
]}

Bohr, Vilhelm A. ^{[1
]}

机构：

[1] NIA, Lab Mol Gerontol, Intramural Res Program, Biomed Res Ctr, Baltimore, MD 21224 USA

[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, BR-14049900 Ribeirao Preto, SP, Brazil

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2015年 / 776卷

基金：

美国国家卫生研究院; 巴西圣保罗研究基金会;

关键词：

Aging; DNA repair; Oxidative damage; Oxidative stress; Neurodegeneration; Alzheimers disease; STRAND BREAK REPAIR; MILD COGNITIVE IMPAIRMENT; INCREASED OXIDATIVE DAMAGE; DEPENDENT PROTEIN-KINASE; HUMAN DERMAL FIBROBLASTS; AGING RAT NEURONS; ALZHEIMERS-DISEASE; MITOCHONDRIAL-DNA; COCKAYNE-SYNDROME; POLYMERASE-BETA;

D O I：

10.1016/j.mrfmmm.2014.12.011

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The aging process and several age-related neurodegenerative disorders have been linked to elevated levels of DNA damage induced by ROS and deficiency in DNA repair mechanisms. DNA damage induced by ROS is a byproduct of cellular respiration and accumulation of damage over time, is a fundamental aspect of a main theory of aging. Mitochondria have a pivotal role in generating cellular oxidative stress, and mitochondrial dysfunction has been associated with several diseases. DNA base excision repair is considered the major pathway for repair of oxidized bases in DNA both in the nuclei and in mitochondria, and in neurons this mechanism is particularly important because non-diving cells have limited backup DNA repair mechanisms. An association between elevated oxidative stress and a decrease in BER is strongly related to the aging process and has special relevance in age-related neurodegenerative diseases. Here, we review the role of DNA repair in aging, focusing on the implications of the DNA base excision repair pathways and how alterations in expression of these DNA repair proteins are related to the aging process and to age-related neurodegenerative diseases. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：31 / 39

页数：9

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