MicroRNAs in hypertrophic cardiomyopathy: pathogenesis, diagnosis, treatment potential and roles as clinical biomarkers

被引：11
作者：
Luo, Fanyan [1 ,2 ]
Liu, Wei [1 ,2 ]
Bu, Haisong [1 ,2 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Cardiovasc Surg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
来源：
HEART FAILURE REVIEWS | 2022年 / 27卷 / 06期
关键词：
MicroRNAs; Hypertrophic cardiomyopathy; Pathogenesis; Biomarkers; Diagnosis; Treatment; SEE VOL. 292; CARDIAC-HYPERTROPHY; CARDIOVASCULAR-DISEASE; ANIMAL-MODEL; REPRESSION; APOPTOSIS; PATHWAY; DYSREGULATION; THERAPEUTICS; DEFICIENCY;
D O I：
10.1007/s10741-022-10231-z
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiomyopathy and is characterized by increased left ventricular wall thickness, but existing diagnostic and treatment approaches face limitations. MicroRNAs (miRNAs) are type of noncoding RNA molecule that plays crucial roles in the pathological process of cardiac remodelling. Accordingly, miRNAs related to HCM may represent potential novel therapeutic targets. In this review, we first discuss the different roles of miRNAs in the development of HCM. We then summarize the roles of common miRNAs as diagnostic and clinical biomarkers in HCM. Finally, we outline current and future challenges and potential new directions for miRNA-based therapeutics for HCM.
引用
收藏
页码：2211 / 2221
页数：11
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