The flavivirus capsid protein: Structure, function and perspectives towards drug design

被引：63

作者：

Oliveira, Edson R. A. ^{[1
]}

Mohana-Borges, Ronaldo ^{[2
]}

de Alencastro, Ricardo B. ^{[1
]}

Horta, Bruno A. C. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Quim Organ, Lab Modelagem Mol, Rio De Janeiro, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Lab Genom Estrutural, Rio De Janeiro, RJ, Brazil

来源：

VIRUS RESEARCH | 2017年 / 227卷

关键词：

Flavivirus; Capsid protein; Drug design; Antiviral; Review; VIRUS CORE PROTEIN; YELLOW-FEVER VIRUS; JAPANESE ENCEPHALITIS-VIRUS; PUBLIC-HEALTH PREPAREDNESS; STRUCTURE-BASED DISCOVERY; N-TERMINAL REGION; DENGUE-VIRUS; ZIKA VIRUS; IN-VITRO; NONSTRUCTURAL PROTEINS;

D O I：

10.1016/j.virusres.2016.10.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Flaviviruses, such as dengue and zika viruses, are etiologic agents transmitted to humans mainly by arthropods and are of great epidemiological interest. The flavivirus capsid protein is a structural element required for the viral nucleocapsid assembly that presents the classical function of sheltering the viral genome. After decades of research, many reports have shown its different functionalities and influence over cell normal functioning. The subcellular distribution of this protein, which involves accumulation around lipid droplets and nuclear localization, also corroborates with its multi-functional characteristic. As flavivirus diseases are still in need of global control and in view of the possible key functionalities that the capsid protein promotes over flavivirus biology, novel considerations arise towards anti-flavivirus drug research. This review covers the main aspects concerning structural and functional features of the flavivirus C protein, ultimately, highlighting prospects in drug discovery based on this viral target. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：115 / 123

页数：9

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