Resveratrol promotes HSV-2 replication by increasing histone acetylation and activating NF-κB

被引：17

作者：

Ding, Liqiong ^{[1
]}

Jiang, Ping ^{[1
]}

Xu, Xinfeng ^{[1
]}

Lu, Wanzhen ^{[1
]}

Yang, Chan ^{[1
]}

Zhou, Pingzheng ^{[1
]}

Liu, Shuwen ^{[1
,2
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou Key Lab Drug Res Emerging Virus Prevent, Guangzhou 510515, Peoples R China

[2] Southern Med Univ, Guangdong Prov Inst Nephrol, State Key Lab Organ Failure Res, Guangzhou 510515, Peoples R China

来源：

BIOCHEMICAL PHARMACOLOGY | 2020年 / 171卷

基金：

中国国家自然科学基金;

关键词：

Resveratrol; Herpes simplex virus 2; Histone acetylation; NF-kappa B; CDK9; SIMPLEX-VIRUS TYPE-1; HERPES; REACTIVATION; INFECTION; TRANSCRIPTION; ASSOCIATION; INHIBITION; EXPRESSION; CDK9; DNA;

D O I：

10.1016/j.bcp.2019.113691

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Resveratrol is a natural compound found in many plant species that has broad therapeutic benefits. Here, we investigated the effects of resveratrol on the replication of HSV-2. We found that resveratrol accelerated replication of HSV-2 and increased release of progeny virion. A time-of-addition study suggested that resveratrol worked primarily in the early stage of viral infection. Resveratrol regulated HSV-2 infection by increasing histone acetylation and activating NF-kappa B. In addition, inhibition of CDK9 activity restrained the promoting effect of resveratrol on HSV-2 infection. Altogether, our experiments revealed the regulatory effect of resveratrol and its mechanism of action on HSV-2 replication.

引用

页数：10

共 41 条

[1] Herpes simplex virus disrupts NF-κB regulation by blocking its recruitment on the IκBα promoter and directing the factor on viral genes [J].