The clinical potential of the acyclic (and cyclic) nucleoside phosphonates. The magic of the phosphonate bond

被引：102

作者：

De Clercq, Erik ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Microbiol & Immunol, Rega Inst Med Res, B-3000 Louvain, Belgium

来源：

BIOCHEMICAL PHARMACOLOGY | 2011年 / 82卷 / 02期

关键词：

Antiviral; Phosphonate; Nucleotide; HEPATITIS-B-VIRUS; ANTIVIRAL ACTIVITY; IN-VITRO; INTRACELLULAR METABOLISM; NUCLEOTIDE ANALOG; DNA-POLYMERASE; SELECTIVE INHIBITOR; ADEFOVIR DIPIVOXIL; ESTER PRODRUGS; HIV-INFECTION;

D O I：

10.1016/j.bcp.2011.03.027

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The use of the acyclic nucleoside phosphonates, starting with (S)-HPMPA as the prototype, yielded three clinically approved antiviral drugs, cidofovir for the treatment of CMV retinitis in AIDS patients, adefovir dipivoxil for the treatment of chronic hepatitis B and tenofovir disoproxil fumarate for the treatment of HIV infections (AIDS) and HBV infections. This era has now grown to many more acyclic (and cyclic) nucleoside phosphonates (such as the "open ring" DAPy and Fd4A phosphonates) and alkoxyalkyl and phosphonoamidate prodrugs thereof, as well as new clinical applications, including new drug combination regimens for the treatment of AIDS, the chemoprophylaxis of HIV infections, and the anticancer potential against some malignant disorders. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：99 / 109

页数：11

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