Human embryonic stem cells:: Current technologies and emerging industrial applications

被引：63
作者：
Ameen, Caroline [1 ]
Strehl, Raimund [1 ]
Bjorquist, Petter [1 ]
Lindahl, Anders [2 ]
Hyllner, Johan [1 ]
Sartipy, Peter [1 ]
机构：
[1] Cellartis AB, Gothenburg 41346, Sweden
[2] Sahlgrens Univ Hosp, Inst Biomed, Dept Clin Chem & Transfus Med, Gothenburg, Sweden
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2008年 / 65卷 / 01期
基金：
美国国家卫生研究院;
关键词：
human embryonic stem cells; differentiation; cardiomyocytes; hepatocytes; drug discovery; toxicology; regenerative medicine;
D O I：
10.1016/j.critrevonc.2007.06.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The efficiency and accuracy of the drug development process is severely restricted by the lack of functional human cell systems. However, the successful derivation of pluripotent human embryonic stem (hES) cell lines in the late 1990s is expected to revolutionize biomedical research in many areas. Due to their growth capacity and unique developmental potential to differentiate into almost any cell type of the human body, hES cells have opened novel avenues both in basic and applied research as well as for therapeutic applications. In this review we describe, from an industrial perspective, the basic science that underlies the hES cell technology and discuss the current and future prospects for hES cells in novel and improved stem cell based applications for drug discovery, toxicity testing as well as regenerative medicine. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：54 / 80
页数：27
相关论文
共 261 条
  • [1] ABRANCHES E, 2006, BIOTECHNOL BIOENG
  • [2] Stem-cell consequences of embryo epigenetic defects
    Allegrucci, C
    Denning, C
    Priddle, H
    Young, L
    [J]. LANCET, 2004, 364 (9429) : 206 - 208
  • [3] Human feeder layers for human embryonic stem cells
    Amit, M
    Margulets, V
    Segev, H
    Shariki, K
    Laevsky, I
    Coleman, R
    Itskovitz-Eldor, J
    [J]. BIOLOGY OF REPRODUCTION, 2003, 68 (06) : 2150 - 2156
  • [4] Feeder layer- and serum-free culture of human embryonic stem cells
    Amit, M
    Shariki, C
    Margulets, V
    Itskovitz-Eldor, J
    [J]. BIOLOGY OF REPRODUCTION, 2004, 70 (03) : 837 - 845
  • [5] Derivation and spontaneous differentiation of human embryonic stem cells
    Amit, M
    Itskovitz-Eldor, J
    [J]. JOURNAL OF ANATOMY, 2002, 200 (03) : 225 - 232
  • [6] 3 MONOCLONAL-ANTIBODIES DEFINING DISTINCT DIFFERENTIATION ANTIGENS ASSOCIATED WITH DIFFERENT HIGH MOLECULAR-WEIGHT POLYPEPTIDES ON THE SURFACE OF HUMAN EMBRYONAL CARCINOMA-CELLS
    ANDREWS, PW
    BANTING, G
    DAMJANOV, I
    ARNAUD, D
    AVNER, P
    [J]. HYBRIDOMA, 1984, 3 (04): : 347 - 361
  • [7] Arai A, 1997, DEV DYNAM, V210, P344, DOI 10.1002/(SICI)1097-0177(199711)210:3<344::AID-AJA13>3.0.CO
  • [8] 2-A
  • [9] Multipotent cell lineages in early mouse development depend on SOX2 function
    Avilion, AA
    Nicolis, SK
    Pevny, LH
    Perez, L
    Vivian, N
    Lovell-Badge, R
    [J]. GENES & DEVELOPMENT, 2003, 17 (01) : 126 - 140
  • [10] Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst
    Baharvand, H
    Ashtiani, SK
    Valojerdi, MR
    Shahverdi, A
    Taee, A
    Sabour, D
    [J]. DIFFERENTIATION, 2004, 72 (05) : 224 - 229
12345678910