Clinical application of plasma thermograms. Utility, practical approaches and considerations

被引：44
作者：
Garbett, Nichola C.
Mekmaysy, Chongkham S.
DeLeeuw, Lynn
Chaires, Jonathan B.
机构：
[1] Univ Louisville, James Graham Brown Canc Ctr, Louisville, KY 40202 USA
[2] Univ Louisville, Dept Med, Div Med Oncol & Hematol, Sch Med, Louisville, KY 40202 USA
来源：
METHODS | 2015年 / 76卷
基金：
美国国家卫生研究院;
关键词：
Differential scanning calorimetry; Thermogram; Plasma; Clinical diagnostics; DIFFERENTIAL SCANNING CALORIMETRY; BLOOD-PLASMA; DSC ANALYSIS; CANCER PATIENTS; PROTEOME; SERUM; DIAGNOSIS;
D O I：
10.1016/j.ymeth.2014.10.030
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Differential scanning calorimetry (DSC) studies of blood plasma are part of an emerging area of the clinical application of DSC to biofluid analysis. DSC analysis of plasma from healthy individuals and patients with various diseases has revealed changes in the thermal profiles of the major plasma proteins associated with the clinical status of the patient. The sensitivity of DSC to the concentration of proteins, their interactions with other proteins or ligands, or their covalent modification underlies the potential utility of DSC analysis. A growing body of literature has demonstrated the versatility and performance of clinical DSC analysis across a range of biofluids and in a number of disease settings. The principles, practice and challenges of DSC analysis of plasma are described in this article. (C) 2014 Elsevier Inc. All rights reserved.
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收藏
页码：41 / 50
页数：10
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