A Point-of-Care Device for Immunosuppressants Monitoring in Transplanted Patients

被引：1

作者：

Berrettoni, C. ^{[1
,2
]}

Trono, C. ^{[2
]}

Tombelli, S. ^{[2
]}

Giannetti, A. ^{[2
]}

Berneschi, S. ^{[2
]}

Baldini, F. ^{[2
]}

Grimaldi, I. A. ^{[3
]}

Persichetti, G. ^{[3
]}

Testa, G. ^{[3
]}

Bernini, R. ^{[3
]}

Porro, G. ^{[4
]}

Gaertner, C. ^{[5
]}

机构：

[1] Univ Siena, Informat Engn & Math Dept, I-53100 Siena, Italy

[2] IFAC CNR, Nello Carrara Inst Appl Phys, I-50019 Sesto Fiorentino, Italy

[3] IREA CNR, Inst Electromagnet Sensing Environm, I-80124 Naples, Italy

[4] Datamed Srl, I-20068 Peschiera Garda, Italy

[5] Microfluid ChipShop GmbH, D-07747 Jena, Germany

来源：

SENSORS | 2015年 / 319卷

关键词：

SYSTEM;

D O I：

10.1007/978-3-319-09617-9_6

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

In the hospital Intensive Care Units (ICU) there is an even greater demand by the physicians for the continuous immunosuppressant drug monitoring in the transplanted patient therapy, in order to avoid different risks and diseases which may occur as result of some drug dosage related effect, such the rejection crisis or sepsis. Here we present a novel design of a point of care testing (POCT) device for the drug dose-adjustment in this kind of patients. The working principle of the device will be discussed. Preliminary tests on the immunoassay strategies for immunosuppressant drugs recognition such as on the optical chip realization and characterization are reported.

引用

页码：27 / 31

页数：5

共 6 条

[1] A newly designed optical biochip for a TDM - POCT device [J].

Berrettoni, C. ;

Trono, C. ;

Berneschi, S. ;

Giannetti, A. ;

Tombelli, S. ;

Bernini, R. ;

Grimaldi, A. ;

Persichetti, G. ;

Testa, G. ;

Bolzoni, L. ;

Porro, G. ;

Becker, H. ;

Gaertner, C. ;

Baldini, F. .

MICROFLUIDICS, BIOMEMS, AND MEDICAL MICROSYSTEMS XII, 2014, 8976

[2] Biochip readout system for point-of-care applications [J].

Brandenburg, Albrecht ;

Curdt, Franziska ;

Sulz, Gerd ;

Ebling, Frank ;

Nestler, Joerg ;

Wunderlich, Kai ;

Michel, Dirk .

SENSORS AND ACTUATORS B-CHEMICAL, 2009, 139 (01) :245-251

[3] Modeling of a Competitive Microfluidic Heterogeneous Immunoassay: Sensitivity of the Assay Response to Varying System Parameters [J].

Fu, Elain ;

Nelson, Kjell E. ;

Ramsey, Stephen A. ;

Foley, Jennifer O. ;

Helton, Kristen ;

Yager, Paul .

ANALYTICAL CHEMISTRY, 2009, 81 (09) :3407-3413

[4] Modeling and experimental verification of the performance of TIRF-sensing systems for oligonucleotide microarrays based on bulk and integrated optical planar waveguides [J].

Lehr, HP ;

Brandenburg, A ;

Sulz, G .

SENSORS AND ACTUATORS B-CHEMICAL, 2003, 92 (03) :303-314

[5] Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclosporin (Neoral®) at day 7 post-renal transplantation and incidence of rejection in the first month [J].

Morris, RG ;

Russ, GR ;

Cervelli, MJ ;

Juneja, R ;

McDonald, SP ;

Mathew, TH .

THERAPEUTIC DRUG MONITORING, 2002, 24 (04) :479-486

[6] Theory of the radiation of dipoles placed within a multilayer system [J].

Polerecki, L ;

Hamrle, J ;

MacCraith, BD .

APPLIED OPTICS, 2000, 39 (22) :3968-3977

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