Isocyanide-based multicomponent reactions in drug discovery

被引：285

作者：

Akritopoulou-Zanze, Irini ^{[1
]}

机构：

[1] Abbott Labs, AP10 101, R4CP, Abbott Pk, IL 60064 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2008年 / 12卷 / 03期

关键词：

D O I：

10.1016/j.cbpa.2008.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review describes recent advances in the application of isocyanide-based multicomponent reactions (IMCRs) in drug discovery and summarizes the various chemotypes used to probe biological targets. In the past couple of years, IMCR-derived ligands have been used to develop agents against infectious diseases and to interfere with protein-protein interactions. Additionally, they were active against a variety of targets such as enzymes, GPCRs and ion channels. The rational for the chemical biologist to apply such diversity generating chemistries is also discussed.

引用

页码：324 / 331

页数：8

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