Expression of Trps1 during mouse embryonic development

被引：27
作者：
Kunath, Melanie
Luedecke, Hermann-Josef
Vortkamp, Andrea
机构：
[1] Max Planck Inst Mol Genet, D-14195 Berlin, Germany
[2] Univ Klinikum, Inst Human Genet, D-45122 Essen, Germany
来源：
MECHANISMS OF DEVELOPMENT | 2002年 / 119卷
关键词：
tricho-rhino-phalangeal syndrome; chondrocyte differentiation; joint formation; hair follicle; gut; lung; kidney;
D O I：
10.1016/S0925-4773(03)00103-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The Trps1 gene codes for an atypical member of the GATA type family of transcription factors. Mutations in human TRPS1 lead to the tricho-rhino-phalangeal syndrome types I and III, which are characterized by craniofacial and skeletal abnormalities and disturbed hair development. Correspondingly, during mouse embryonic development strong Trps1 expression is found in the cartilage condensations, the developing joints, the hair follicles and in the developing snout. In addition, Trps1 is expressed surrounding the skeletal condensations, in the trachea, the intervertebral disks, and in lung and gut mesenchyme. A complex pattern of expression is also found in the developing brain. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：S117 / S120
页数：4
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