Insights into the role of STAT3 in intrahepatic cholangiocarcinoma

被引：11
作者：
Yang, Ranzhiqiang [1 ]
Song, Yinghui [1 ,2 ]
Shakoor, Kashif [1 ]
Yi, Weimin [1 ]
Peng, Chuang [1 ,3 ]
Liu, Sulai [1 ,2 ,3 ]
机构：
[1] First Affiliated Hosp Hunan Normal Univ, Dept Hepatobiliary Surg, Changsha 410005, Hunan, Peoples R China
[2] First Affiliated Hosp Hunan Normal Univ, Hunan Prov Peoples Hosp, Cent Lab, Changsha 410005, Hunan, Peoples R China
[3] First Affiliated Hosp Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Hepatobiliary Surg, 61 Jiefang Rd, Changsha 410005, Hunan, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2022年 / 25卷 / 05期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
signal transducer and activator of transcription 3; intrahepatic cholangiocarcinoma; FIBROBLAST ACTIVATION PROTEIN; CANCER-ASSOCIATED FIBROBLASTS; 2; SH2; DOMAIN; SIGNAL TRANSDUCER; TRANSCRIPTION; GASTRIC-CANCER; PHASE-I; TYROSINE PHOSPHORYLATION; TUMOR MICROENVIRONMENT; CELLS;
D O I：
10.3892/mmr.2022.12687
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Intrahepatic cholangiocarcinoma (ICC) is a primary malignant liver tumour whose incidence is second only to that of hepatocellular carcinoma. ICC is a highly heterogeneous disease arising from neoplastic transformation of intrahepatic biliary epithelial cells (cholangiocytes), and it is characterized by a very poor prognosis. Signal transducer and activator of transcription 3 (STAT3) is an important oncogene that is widely expressed in numerous cancers. STAT3 is a candidate target for the treatment of ICC. However, studies on STAT3 and the occurrence and development of ICC require improvements. Therefore, the present review summarized the mechanism of STAT3 in ICC and provided a theoretical basis for STAT3 to become an effective target for determining the prognosis and treatment of ICC.
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页数：8
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