Immunopathological aspects of age-related macular degeneration

被引：136
作者：
Patel, Mrinali [1 ,2 ]
Chan, Chi-Chao [1 ]
机构：
[1] NEI, Immunopathol Sect, Immunol Lab, NIH, Bethesda, MD 20892 USA
[2] Howard Hughes Med Inst, Chevy Chase, MD USA
来源：
SEMINARS IN IMMUNOPATHOLOGY | 2008年 / 30卷 / 02期
关键词：
age-relatedmacular degeneration (AMD); inflammation; complement; macrophage; microglia;
D O I：
10.1007/s00281-008-0112-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Age-related macular degeneration (AMD) represents a leading cause of blindness worldwide. While the clinical and histopathological aspects of AMD are well characterized, its etiology and pathogenesis remain unclear. Recent findings suggest a role for immunologic processes in AMD pathogenesis, including the age-related generation of extracellular deposits inside the Brusch membrane and beneath the retinal pigment epithelium, recruitment of macrophages for clearance of these deposits, complement activation, recruitment of tissue-destructive macrophages, microglial activation and accumulation, and proinflammatory effects of chronic inflammation by Chlamydia pneumoniae. This review discusses the evidence for the role of inflammation in human AMD and in animal models of AMD.
引用
收藏
页码：97 / 110
页数：14
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