Regulation of Ferroptosis by Amino Acid Metabolism in Cancer

被引：42

作者：

Yang, Jian

Dai, Xinyu

Xu, Huanji

Tang, Qiulin

Bi, Feng ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Med Oncol, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2022年 / 18卷 / 04期

基金：

中国国家自然科学基金;

关键词：

amino acid metabolism; ferroptosis; cancer; combinatorial therapy; CELL-DEATH; OXIDATIVE STRESS; GLUTAMINE UPTAKE; TRANSSULFURATION PATHWAY; ALLOSTERIC INHIBITORS; SERINE BIOSYNTHESIS; GLUTATHIONE; CYSTEINE; CONTRIBUTES; MECHANISMS;

D O I：

10.7150/ijbs.64982

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferroptosis, a new form of programmed necrosis characterized by iron-dependent lethal accumulation of lipid hydroperoxides, is associated with many human diseases. Targeting amino acid (AA) availability can selectively suppress tumor growth and has been a promising therapeutic strategy for cancer therapy. Compelling studies have indicated that AA metabolism is also involved in ferroptosis, closely regulating its initiation and execution. This manuscript systematically summarizes the latest advances of AA metabolism in regulating ferroptosis and discusses the potential combination of therapeutic strategies that simultaneously target AA metabolism and ferroptosis in cancer to eliminate tumors or limit their invasiveness.

引用

页码：1695 / 1705

页数：11

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