Association of vitamin B12 mediated hyperhomocysteinemia and methylenetetrafolate reductase (C677T) gene polymorphism with cognitive impairment: A population based study from North India

被引：11
作者：
Kaur, Gurjinder [1 ]
Gaur, Rajan [1 ]
Yadav, Suniti [2 ]
Saraswathy, Kallur Nava [2 ]
机构：
[1] Panjab Univ, Dept Anthropol, Chandigarh 160014, India
[2] Univ Delhi, Dept Anthropol, New Delhi 110007, India
来源：
PSYCHIATRY RESEARCH | 2018年 / 270卷
关键词：
Cognitive impairment; Hyperhomocysteinemia; MTHFR C677T gene polymorphism; METHYLENETETRAHYDROFOLATE REDUCTASE; HOMOCYSTEINE; MUTATION; DISEASE; RISK;
D O I：
10.1016/j.psychres.2018.08.103
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The present study attempts to understand the association of homocysteine, vitamin B12, folate, and MTHFR C677T gene polymorphism with cognitive impairment (CI) among 808 individuals of either sex (aged 30-70 years) from a largely vegetarian, mendelian population of North India. Biochemical and genetic analyses were done using standard protocols. Results indicate that 34.3% of the subjects had mild CI, 28.7% moderate CI and 0.2% were having severe CI. Hyperhomocysteinemia was found to be a significant risk factor for moderate/severe CI. Both CT genotype and T allele of MTHFR C677T gene polymorphism were found to pose significant decreased risk for CI.
引用
收藏
页码：123 / 125
页数：3
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