Copper-Catalyzed Alkynylboration of Alkenes with Diboron Reagents and Bromoalkynes

被引：32
作者：
Gong, Tian-Jun [1 ]
Yu, Shang-Hai [1 ]
Li, Kuan [1 ]
Su, Wei [1 ]
Lu, Xi [1 ]
Xiao, Bin [1 ]
Fu, Yao [1 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Anhui Prov Key Lab Biomass Clean Energy, CAS Key Lab Urban Pollutant Convers,IChEM, Hefei 230026, Anhui, Peoples R China
来源：
CHEMISTRY-AN ASIAN JOURNAL | 2017年 / 12卷 / 22期
基金：
中国国家自然科学基金;
关键词：
boration; copper; cross-coupling; difunctionalization; synthetic methods; CROSS-COUPLING REACTIONS; COPPER(I)-CATALYZED REACTION; REGIOSELECTIVE ARYLBORATION; SONOGASHIRA REACTIONS; ALKYL ELECTROPHILES; C(SP(3))-H BONDS; HYDROBORATION; ARYL; HALIDES; ALKYNYLATION;
D O I：
10.1002/asia.201701176
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient method for the synthesis of homopropargylboronates by copper-catalyzed alkynylboration of alkenes with diboron reagents and bromoalkynes has been developed. The alkynylboration reaction features high selectivity and efficiency, mild reaction conditions, wide substrate scope, and functional-group compatibility, and is a highly attractive complement to existing methods for the synthesis of homopropargylboronates. Both the boryl and alkynyl groups are good potential functional groups for the subsequent manipulations that provide access to a variety of important molecule structures.
引用
收藏
页码：2884 / 2888
页数：5
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