Membrane device for holding biomolecule samples for terahertz spectroscopy

被引:22
作者
Yoneyama, H. [1 ]
Yamashita, M. [1 ]
Kasai, S. [1 ,2 ]
Kawase, K. [1 ]
Ito, H. [1 ]
Ouchi, T. [1 ,2 ]
机构
[1] RIKEN, Terahertz Biol Sensing Res Lab, Wako, Saitama 3510198, Japan
[2] Canon Inc, Canon Res Ctr, Tokyo 1468501, Japan
关键词
membrane device; Ti : sapphire laser; biosensing;
D O I
10.1016/j.optcom.2007.03.089
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
A device for holding biomolecule samples on a membrane allows scanning using terahertz frequency waves. Such scanning has previously been difficult due to the strong attenuation of terahertz frequency waves by water. Several types of biomolecules were scanned using terahertz time domain spectroscopy (TDS), and the data showed clear differences in transmittance among the samples. This membrane device is a promising aid for research on biomolecules using terahertz waves. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:1909 / 1913
页数:5
相关论文
共 10 条
[1]   Label-free probing of the binding state of DNA by time-domain terahertz sensing [J].
Brucherseifer, M ;
Nagel, M ;
Bolivar, PH ;
Kurz, H ;
Bosserhoff, A ;
Büttner, R .
APPLIED PHYSICS LETTERS, 2000, 77 (24) :4049-4051
[2]   Contact line deposits in an evaporating drop [J].
Deegan, RD ;
Bakajin, O ;
Dupont, TF ;
Huber, G ;
Nagel, SR ;
Witten, TA .
PHYSICAL REVIEW E, 2000, 62 (01) :756-765
[3]   Terahertz time-domain spectroscopy and imaging of artificial RNA [J].
Fischer, BM ;
Hoffmann, M ;
Helm, H ;
Wilk, R ;
Rutz, F ;
Kleine-Ostmann, T ;
Koch, M ;
Jepsen, PU .
OPTICS EXPRESS, 2005, 13 (14) :5205-5215
[4]   LYOPHILIZATION-INDUCED REVERSIBLE CHANGES IN THE SECONDARY STRUCTURE OF PROTEINS [J].
GRIEBENOW, K ;
KLIBANOV, AM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (24) :10969-10976
[5]   Hydration dependence of conformational dielectric relaxation of lysozyme [J].
Knab, J ;
Chen, JY ;
Markelz, A .
BIOPHYSICAL JOURNAL, 2006, 90 (07) :2576-2581
[6]   THz time domain spectroscopy of biomolecular conformational modes [J].
Markelz, A ;
Whitmire, S ;
Hillebrecht, J ;
Birge, R .
PHYSICS IN MEDICINE AND BIOLOGY, 2002, 47 (21) :3797-3805
[7]   Pulsed terahertz spectroscopy of DNA, bovine serum albumin and collagen between 0.1 and 2.0 THz [J].
Markelz, AG ;
Roitberg, A ;
Heilweil, EJ .
CHEMICAL PHYSICS LETTERS, 2000, 320 (1-2) :42-48
[8]   Integrated THz technology for label-free genetic diagnostics [J].
Nagel, M ;
Bolivar, PH ;
Brucherseifer, M ;
Kurz, H ;
Bosserhoff, A ;
Büttner, R .
APPLIED PHYSICS LETTERS, 2002, 80 (01) :154-156
[9]   Far-infrared vibrational modes of polycrystalline saccharides [J].
Upadhya, PC ;
Shen, YC ;
Davies, AG ;
Linfield, EH .
VIBRATIONAL SPECTROSCOPY, 2004, 35 (1-2) :139-143
[10]   Submillimeter-wave phonon modes in DNA macromolecules [J].
Woolard, D.L. ;
Globus, T.R. ;
Gelmont, B.L. ;
Bykhovskaia, M. ;
Samuels, A.C. ;
Cookmeyer, D. ;
Hesler, J.L. ;
Crowe, T.W. ;
Jensen, J.O. ;
Jensen, J.L. ;
Loerop, W.R. .
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 2002, 65 (05) :1-051903