Self-reported medication adherence and treatment satisfaction in patients with epilepsy

被引:122
作者
Sweileh, Waleed M. [1 ]
Ihbesheh, Manal S. [2 ]
Jarar, Ikhlas S.
Abu Taha, Adham S.
Sawalha, Ansam F.
Zyoud, Sa'ed H. [3 ]
Jamous, Raniah M.
Morisky, Donald E. [4 ]
机构
[1] An Najah Natl Univ, Dept Pharmacol & Toxicol, Sch Pharm, Coll Pharm, Nablus, Israel
[2] An Najah Natl Univ, Dept Biochem, Coll Pharm, Nablus, Israel
[3] Univ Sains Malaysia, WHO Collaborating Ctr Drug Informat, Natl Poison Ctr, George Town, Malaysia
[4] Univ Calif Los Angeles, Sch Publ Hlth, Dept Community Hlth Sci, Los Angeles, CA 90024 USA
关键词
Adherence; Satisfaction; Epilepsy; Palestine; Antiepileptic drug; QUALITY-OF-LIFE; ANTIEPILEPTIC DRUG-THERAPY; PREDICTIVE-VALIDITY; SEIZURES; NONADHERENCE; CARE; QUESTIONNAIRE; ASSOCIATION; MANAGEMENT; PHYSICIANS;
D O I
10.1016/j.yebeh.2011.04.011
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Objective: Reports about medication adherence and satisfaction in patients with epilepsy in Arab countries are lacking. The objective of this study was to assess medication adherence and its relationship with treatment satisfaction, number of antiepileptic drugs (AEDs) taken, and epilepsy control in a sample of Palestinian patients. Methods: This cross-sectional descriptive study was carried out at Al-Makhfya Governmental Outpatient Center in Nablus, Palestine, during the summer of 2010. A convenience sampling method was used to select patients over the study period. Medication adherence was measured using the eight-item Morisky Medication Adherence Scale (MMAS); treatment satisfaction was measured using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Epilepsy was arbitrarily defined as "well controlled" if the patient had had no seizures in the last 3 months and was defined as "poorly controlled" if he or she had had at least one seizure in the last 3 months. Results: A convenience sample of 75 patients was studied. On the basis of the MMAS, 11 patients (14.7%) had a low rate, 37 (49.3%) had a medium rate, and 27 (36%) had a high rate of adherence. Adherence was positively and significantly correlated with age (P = 0.02) and duration of illness (P = 0.01). No significant difference in adherence was found between patients with well-controlled and those with poorly controlled epilepsy. Similarly, there was no significant difference in adherence between patients on monotherapy and those on polytherapy. Mean satisfaction with respect to effectiveness, side effects, convenience, and global satisfaction were 73.6 +/- 20.7, 82.4 +/- 29.8, 69.5 +/- 15.5, and 68.4 +/- 18.3, respectively. There were significant differences in mean values in the effectiveness (P<0.01) and convenience (P<0.01) domains, but not the side effect (P = 0.1) and global satisfaction (P = 0.08) domains among patients with different levels of adherence. Patients on monotherapy had significantly higher satisfaction in the effectiveness domain (P = 0.04) than patients on polytherapy. Similarly, patients with well-controlled epilepsy scored significantly higher in the Effectiveness (P = 0.01) and Global Satisfaction (P = 0.01) domains than those with poorly controlled epilepsy. Conclusion: In our convenience sample, we found that adherence to and satisfaction with AEDs were moderate and were not associated with seizure control or number of AEDs. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:301 / 305
页数:5
相关论文
共 46 条
[31]   CONCURRENT AND PREDICTIVE-VALIDITY OF A SELF-REPORTED MEASURE OF MEDICATION ADHERENCE [J].
MORISKY, DE ;
GREEN, LW ;
LEVINE, DM .
MEDICAL CARE, 1986, 24 (01) :67-74
[32]   RETRACTED: Predictive Validity of a Medication Adherence Measure in an Outpatient Setting (Retracted article. See AUG, 2023) [J].
Morisky, Donald E. ;
Ang, Alfonso ;
Krousel-Wood, Marie ;
Ward, Harry J. .
JOURNAL OF CLINICAL HYPERTENSION, 2008, 10 (05) :348-354
[33]  
PARKERSON K, 2009, J CLIN OUTCOMES MANA, V16, P468
[34]   DETERMINANTS OF PATIENT COMPLIANCE WITH ANTI-CONVULSANT THERAPY [J].
PETERSON, GM ;
MCLEAN, S ;
MILLINGEN, KS .
EPILEPSIA, 1982, 23 (06) :607-613
[35]  
Rosenfeld WE, 2004, EPILEPSIA, V45, P238
[36]   European survey of the level of satisfaction of patients and physicians in the management of epilepsy in general practice [J].
Ross, John ;
Stefan, Hermann ;
Schaeuble, Barbara ;
Day, Richard ;
Sander, Josemir W. .
EPILEPSY & BEHAVIOR, 2010, 19 (01) :36-42
[37]  
Schmidt D, 1988, Epilepsy Res Suppl, V1, P141
[38]  
Schommer JC, 1997, AM J HEALTH-SYST PH, V54, P2721
[39]   Does antiepileptic drug therapy prevent the development of ''chronic'' epilepsy? [J].
Shinnar, S ;
Berg, AT .
EPILEPSIA, 1996, 37 (08) :701-708
[40]  
Shope J T, 1988, Epilepsy Res Suppl, V1, P23