Association of Vitamin B12 with Pro-Inflammatory Cytokines and Biochemical Markers Related to Cardiometabolic Risk in Saudi Subjects

被引：42

作者：

Al-Daghri, Nasser M. ^{[1
,2
]}

Rahman, Shakilur ^{[1
,2
]}

Sabico, Shaun ^{[1
,2
]}

Yakout, Sobhy ^{[1
,2
]}

Wani, Kaiser ^{[1
,2
]}

Al-Attas, Omar S. ^{[1
,2
]}

Saravanan, Ponnusamy ^{[3
]}

Tripathi, Gyanendra ^{[1
,2
,4
,5
]}

McTernan, Philip G. ^{[4
]}

Alokail, Majed S. ^{[1
,2
]}

机构：

[1] King Saud Univ, Dept Biochem, Coll Sci, Biomarkers Res Program, Riyadh 11451, Saudi Arabia

[2] King Saud Univ, Dept Biochem, Coll Sci, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh 11451, Saudi Arabia

[3] Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry CV4 7AL, W Midlands, England

[4] Univ Warwick, Warwick Med Sch, Div Biomed Sci, UHCW Trust, Clifford Bridge Rd, Coventry CV2 2DX, W Midlands, England

[5] Univ Westminster, Dept Biomed Sci, London W1W 6UW, England

来源：

NUTRIENTS | 2016年 / 8卷 / 09期

关键词：

vitamin B12; resistin; TNF-; cardiometabolic diseases; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; TNF-ALPHA; HYPERHOMOCYSTEINEMIA; HOMOCYSTEINE; DEFICIENCY; OBESITY; MICRONUTRIENT;

D O I：

10.3390/nu8090460

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: This study aimed to examine the relationship between changes in systemic vitamin B12 concentrations with pro-inflammatory cytokines, anthropometric factors and biochemical markers of cardiometabolic risk in a Saudi population. Methods: A total of 364 subjects (224 children, age: 12.99 +/- 2.73 (mean +/- SD) years; BMI: 20.07 +/- 4.92 kg/m(2) and 140 adults, age: 41.87 +/- 8.82 years; BMI: 31.65 +/- 5.77 kg/m(2)) were studied. Fasting blood, anthropometric and biochemical data were collected. Serum cytokines were quantified using multiplex assay kits and B12 concentrations were measured using immunoassay analyzer. Results: Vitamin B12 was negatively associated with TNF- (r = -0.14, p < 0.05), insulin (r = -0.230, p < 0.01) and HOMA-IR (r = -0.252, p < 0.01) in all subjects. In children, vitamin B12 was negatively associated with serum resistin (r = -0.160, p < 0.01), insulin (r = -0.248, p < 0.01), HOMA-IR (r = -0.261, p < 0.01). In adults, vitamin B12 was negatively associated with TNF- (r = -0.242, p < 0.01) while positively associated with resistin (r = 0.248, p < 0.01). Serum resistin was the most significant predictor for circulating vitamin B12 in all subjects (r(2) = -0.17, p < 0.05) and in children (r(2) = -0.167, p < 0.01) while HDL-cholesterol was the predictor of B12 in adults (r(2) = -0.78, p < 0.05). Conclusions: Serum vitamin B12 concentrations were associated with pro-inflammatory cytokines and biochemical markers of cardiometabolic risks in adults. Maintaining adequate vitamin B12 concentrations may lower inflammation-induced cardiometabolic risk in the Saudi adult population.

引用

页数：8

共 35 条

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