Chemoprevention of NMU-induced rat mammary carcinoma with the combination of melatonin and 9-cis-retinoic acid

被引：31

作者：

Teplitzky, SR

Kiefer, TL

Cheng, Q

Dwivedi, PD

Moroz, K

Myers, L

Anderson, MB

Collins, A

Dai, J

Yuan, L

Spriggs, LL

Blask, DE

Hill, SM

机构：

[1] Tulane Univ, Sch Med, Dept Struct & Cellular Biol, New Orleans, LA 70112 USA

[2] Tulane Univ, Sch Med, Dept Surg, New Orleans, LA 70112 USA

[3] Tulane Univ, Sch Med, Dept Pathol, New Orleans, LA 70112 USA

[4] Tulane Univ, Sch Med, Dept Biostat, New Orleans, LA 70112 USA

[5] Tulane Univ, Sch Med, Mol & Cellular Biol Grad Program, New Orleans, LA 70112 USA

[6] Tulane Univ, Sch Med, Tulane Canc Ctr, New Orleans, LA 70112 USA

[7] Mary Imogene Bassett Res Inst, Cooperstown, NY 13326 USA

来源：

CANCER LETTERS | 2001年 / 168卷 / 02期

关键词：

melatonin; 9-cis-retinoic acid; breast cancer;

D O I：

10.1016/S0304-3835(01)00548-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In experimental trials using the N-nitroso-N-methylurea (NMU)-induced rat mammary tumor model, a significant decrease in tumor incidence (to 5%) was observed in rats treated with melatonin and 9-cis-retinoic acid (9 cRA) compared to controls (55%). Although 9cRA alone decreased tumor incidence to 26%, this response did not reach statistical significance. Tumor incidence was significantly inhibited to 20% in the animals that received melatonin and 9cRA on alternating days. Latency to tumor onset was prolonged in animals receiving either of the combination treatments compared with controls, and tumor multiplicity was also significantly decreased. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：155 / 163

页数：9

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