Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?

被引：33

作者：

Evliyaoglu, Olcay ^{[1
]}

Acar, Manolya ^{[1
]}

Ozcabi, Bahar ^{[1
]}

Erginoz, Ethem ^{[2
]}

Bucak, Feride ^{[1
]}

Ercan, Oya ^{[1
]}

Kucur, Mine ^{[3
]}

机构：

[1] Istanbul Univ, Cerrahpasa Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey

[2] Istanbul Univ, Cerrahpasa Fac Med, Dept Publ Hlth, Istanbul, Turkey

[3] Istanbul Univ, Cerrahpasa Fac Med, Dept Biochem, Istanbul, Turkey

来源：

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY | 2015年 / 7卷 / 02期

关键词：

Hashimoto thyroiditis; vitamin D; deficiency; children; adolescents; 1,25-DIHYDROXYVITAMIN D-3; D-RECEPTOR; AUTOIMMUNE-DISEASE; TARGET; RISK; ENCEPHALOMYELITIS; ANALOG; CELLS; GENE; 25-HYDROXYVITAMIN-D;

D O I：

10.4274/jcrpe.2011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients. Methods: This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 +/- 2.87 years) and 79 age-matched healthy controls (11.85 +/- 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects. Results: The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 +/- 11.65 vs. 20.99 +/- 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH) D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3). Conclusion: Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.

引用

页码：128 / 133

页数：6

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