Could Fahr's Syndrome Have More Than One Simultaneous Etiology?

被引:2
作者
Palu, Gabriele [1 ]
Moraes, Samia T. [1 ]
Romaniello, Gabriela [1 ]
Zatorre, Luis O. [1 ]
Seixas, Luiza K. [1 ]
Miyazima, Rafael [1 ]
Marques, Gustavo Lenci [1 ,2 ]
机构
[1] Univ Fed Parana, Internal Med Dept, Curitiba, Parana, Brazil
[2] Pontificia Univ Catolica Parana, Med Dept, Curitiba, Parana, Brazil
关键词
secondary hypocalcemia; cerebral calcifications; new-onset seizure; hypoparathyroidism; fahr's disease or fahr's syndrome; BASAL GANGLIA CALCIFICATION; HYPOPARATHYROIDISM; DIAGNOSIS; MANAGEMENT;
D O I
10.7759/cureus.20342
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fahr's syndrome is a rare, genetically dominant, inherited, neurological disorder characterized by abnormal deposits of calcium in the basal ganglia and the cerebral cortex. Symptoms include motor dysfunction, dementia, headache, spastic paralysis, abnormal ocular findings and seizures. Hypoparathyroidism is the most common endocrine disorder related to this syndrome, however, there are other metabolic, infectious and genetic causes. This is a case report of a Fahr's syndrome patient presenting a three-month history of self-limited partial epileptic seizures. His cranial C:T had bilateral symmetrical calcifications of the basal ganglia, subcortical tissue and dentate nucleus whereas his laboratory findings were compatible with hypoparathyroidism.
引用
收藏
页数:5
相关论文
共 20 条
  • [1] Amisha F., 2021, StatPearls
  • [2] Deconstructing Fahr's disease/syndrome of brain calcification in the era of new genes
    Batla, Amit
    Tai, Xin You
    Schottlaender, Lucia
    Erro, Robert
    Balint, Bettina
    Bhatia, Kailash P.
    [J]. PARKINSONISM & RELATED DISORDERS, 2017, 37 : 1 - 10
  • [3] Diagnosis and classification of autoimmune parathyroid disease
    Betterle, Corrado
    Garelli, Silvia
    Presotto, Fabio
    [J]. AUTOIMMUNITY REVIEWS, 2014, 13 (4-5) : 417 - 422
  • [4] Hypoparathyroidism
    Bilezikian, John P.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 105 (06) : 1722 - 1736
  • [5] Management of Hypoparathyroidism: Present and Future
    Bilezikian, John P.
    Brandi, Maria Luisa
    Cusano, Natalie E.
    Mannstadt, Michael
    Rejnmark, Lars
    Rizzoli, Rene
    Rubin, Mishaela R.
    Winer, Karen K.
    Liberman, Uri A.
    Potts, John T., Jr.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (06) : 2313 - 2324
  • [6] Hypoparathyroidism in the Adult: Epidemiology, Diagnosis, Pathophysiology, Target-Organ Involvement, Treatment, and Challenges for Future Research
    Bilezikian, John P.
    Khan, Aliya
    Potts, John T., Jr.
    Brandi, Maria Luisa
    Clarke, Bart L.
    Shoback, Dolores
    Jueppner, Harald
    D'Amour, Pierre
    Fox, John
    Rejnmark, Lars
    Mosekilde, Leif
    Rubin, Mishaela R.
    Dempster, David
    Gafni, Rachel
    Collins, Michael T.
    Sliney, Jim
    Sanders, James
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2011, 26 (10) : 2317 - 2337
  • [7] Diagnosis and management of hypocalcaemia
    Cooper, Mark S.
    Gittoes, Neil J. L.
    [J]. BRITISH MEDICAL JOURNAL, 2008, 336 (7656): : 1298 - 1302
  • [8] Dembele Kekouta, 2019, eNeurologicalSci, V15, P100192, DOI 10.1016/j.ensci.2019.100192
  • [9] Fahr's syndrome presenting with seizures in SARS-CoV-2 (COVID-19) pneumonia-a case report
    Demir, Gurkan
    Balaban, Onur
    Tekeci, Muhammet Halit
    Issi, Zeynep
    Erdem, Ali Fuat
    [J]. NEUROLOGICAL SCIENCES, 2020, 41 (11) : 3063 - 3065
  • [10] Basal ganglia calcifications (Fahr's syndrome): related conditions and clinical features
    Donzuso, Giulia
    Mostile, Giovanni
    Nicoletti, Alessandra
    Zappia, Mario
    [J]. NEUROLOGICAL SCIENCES, 2019, 40 (11) : 2251 - 2263