Is There a Specific Pattern of Attention Deficit in Mild Cognitive Impairment with Subcortical Vascular Features? Evidence from the Attention Network Test

被引:35
作者
Fernandez, Pedro J. [1 ]
Campoy, Guillermo [1 ]
Garcia Santos, Jose M. [2 ]
Antequera, Martirio M. [3 ]
Garcia-Sevilla, Julia [1 ]
Castillo, Alejandro [1 ]
Antunez, Carmen [3 ]
Fuentes, Luis J. [1 ]
机构
[1] Univ Murcia, Murcia, Spain
[2] Hosp Morales Meseguer, Murcia, Spain
[3] Univ Hosp Virgen Arrixaca, Murcia, Spain
关键词
Attention network test; Vascular mild cognitive impairment; Cholinergic system; CORTICAL CHOLINERGIC INPUTS; ALZHEIMERS-DISEASE; BASAL FOREBRAIN; MULTIINFARCT DEMENTIA; HUMAN BRAIN; TIME-COURSE; MEMORY; INDEPENDENCE; MODULATION; ALERTNESS;
D O I
10.1159/000327165
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: Mild cognitive impairment (MCI) is an intermediate state between normal aging and early dementia. Some MCI patients show white matter hyperintensities in magnetic resonance imaging, revealing subcortical vascular damage (SVD). This study aimed to evaluate potential attention deficits not previously described in these patients. Specifically, we evaluated attention network functioning in MCI on the basis of Posner's cognitive neuroscience model, which considers attention as a set of networks: alerting, orienting and executive control. Methods: Three groups of participants were tested: 19 MCI patients with SVD (svMCI), 15 MCI patients free from SVD (nvMCI) and 19 healthy controls (HC). We used a task in which the three attention networks and their interactions can be assessed simultaneously, the Attention Network Test (ANT). Results: The svMCI group showed smaller orienting effect compared with the nvMCI and HC groups. In contrast to the HC and nvMCI groups, svMCI patients did not show improvement in the executive network from the valid visual cue. Conclusions: svMCI patients show a deficit in orienting attention networks. This deficit could be related to an effect of SVD on the cholinergic system because acetylcholine is implicated in the modulation of covert orienting responses of attention. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:268 / 275
页数:8
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