Transition-Metal-Free Acylation of Quinolines and Isoquinolines with Arylmethanols via Oxidative Cross-Dehydrogenative Coupling Reactions

被引：20
作者：
Adib, Mehdi [1 ]
Pashazadeh, Rahim [1 ]
Rajai-Daryasarei, Saideh [1 ]
Kabiri, Roya [2 ]
Gohari, Seyed Jamal Addin [3 ]
机构：
[1] Univ Tehran, Sch Chem, Coll Sci, POB 14155-6455, Tehran, Iran
[2] Tabriz Univ, NMR Lab, Fac Chem, Tabriz, Iran
[3] Imam Hossein Univ, Dept Chem, Tehran, Iran
来源：
SYNLETT | 2016年 / 27卷 / 15期
关键词：
cross-dehydrogenative coupling reaction; C-C bond formation; metal-free coupling reaction; K2S2O8; Aliquat; 336; 2-aroyl quinolones; 1-aroyl isoquinolines; N-HETEROCYCLES; TETRAHYDROISOQUINOLINES; ALDEHYDES; STRATEGY; DIVERSE; DESIGN; BONDS; SCOPE;
D O I：
10.1055/s-0035-1562135
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient acylation of quinolines and isoquinolines is described by use of arylmethanols as the acylating agents through a C-C bond formation via an oxidative cross-dehydrogenative coupling (CDC) strategy. This C-aroylation reaction was carried out by use of K2S2O8 as oxidant and methyltrioctylammonium chloride (Aliquat 336) as a transfer agent in MeCN at 80 degrees C under transition-metal-free conditions.
引用
收藏
页码：2241 / 2245
页数：5
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