Concentration of vascular endothelial growth factor in the tumour tissue as a prognostic factor of soft tissue sarcomas

被引:99
|
作者
Yudoh, K [1 ]
Kanamori, N [1 ]
Ohmori, K [1 ]
Yasuda, T [1 ]
Aoki, M [1 ]
Kimura, T [1 ]
机构
[1] Toyama Med & Pharmaceut Univ, Dept Orthopaed Surg, Toyama, Japan
关键词
microvessel density; vascular endothelial growth factor; overall survival; tumour recurrence; metastasis; soft tissue sarcoma;
D O I
10.1054/bjoc.2001.1837
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Previous studies have shown that the prognosis of patients who have tumours with high microvessel density (MVD) is worse than that of patients who have a lower density in a variety of cancers. In this study, we investigated the clinical relevance of neovascularity assessed by MVD and the concentration of vascular endothelial growth factor (WEGF) in the tumour tissue of patients with soft tissue sarcoma in comparison with major clinicohistologic parameters by univariate and multivariate analysis. In 115 patients with soft tissue sarcoma, MVD was measured by counting vessels stained with factor VIII antibody. The concentration of VEGF in the tumour tissue was determined by enzyme-linked immunosorbent assay. These parameters were then compared with disease outcome. The concentration of VEGF in the tumour tissue, but not MVD, was round to be correlated with disease outcome in patients with soft tissue, sarcoma. VEGF concentration in the tumour tissue showed a relationship with the clinical stage and histologic grade of the tumour. There was no significant difference in the levels of tissue VEGF concentration and MVD among soft tissue sarcomas classified according to histologic type. The level of tissue VEGF concentration in patients who had subsequent local recurrence and metastasis were significantly higher than the respective values in patients who did not have such disease outcome. No significant correlation existed between MVD and the concentration of VEGF in the tumour tissue. Univariate analysis showed that a high tissue VEGF concentration was associated with poor overall survival of the patient and a greater probability that local recurrence and metastasis had occurred. Multivariate analysis revealed that the tissue concentration of VEGF is an independent prognostic factor for the disease outcome of patients with sofi tissue sarcoma. VEGF concentration in the tumour tissue, but not MVD, is an additional prognostic parameter for disease outcome in patients with soft tissue sarcoma, regardless of histologic type. (C) 2001 Cancer Research Campaign.
引用
收藏
页码:1610 / 1615
页数:6
相关论文
共 50 条
  • [31] TISSUE FACTOR PATHWAY INHIBITOR REGULATES ANGIOGENESIS INDEPENDENTLY OF TISSUE FACTOR VIA INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALLING
    Holroyd, E. W.
    Larsen, K.
    Vile, R. G.
    Mukhopadhyay, D.
    Simari, R. D.
    HEART, 2011, 97 : A80 - A80
  • [32] Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer
    Nakasaki, T
    Wada, H
    Shigemori, C
    Miki, C
    Gabazza, EC
    Nobori, T
    Nakamura, S
    Shiku, H
    AMERICAN JOURNAL OF HEMATOLOGY, 2002, 69 (04) : 247 - 254
  • [33] Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor
    Abe, K
    Shoji, M
    Chen, J
    Bierhaus, A
    Danave, I
    Micko, C
    Casper, K
    Dillehay, DL
    Nawroth, PP
    Rickles, FR
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) : 8663 - 8668
  • [34] Vascular endothelial growth factor overexpression by soft tissue sarcoma cells: Implications for tumor growth, metastasis, and chemoresistance
    Zhang, Lianglin
    Hannay, Jonathan A. F.
    Liu, Juehui
    Das, Parimal
    Zhan, Maocheng
    Nguyen, Theresa
    Hicklin, Daniel J.
    Yu, Dihua
    Pollock, Raphael E.
    Lev, Dina
    CANCER RESEARCH, 2006, 66 (17) : 8770 - 8778
  • [35] Chemiluminescence immunoassay for vascular endothelial growth factor (vascular permeability factor) in tumor-tissue homogenates
    Schlaeppi, JM
    Eppenberger, U
    MartinyBaron, G
    Kung, W
    CLINICAL CHEMISTRY, 1996, 42 (11) : 1777 - 1784
  • [36] Topical Single-dose Vascular Endothelial Growth Factor has No Effect on Soft Tissue Healing
    Bolukbasi, Nilufer
    Balcioglu, Huseyin Avni
    Ozkan, Birkan T.
    Tekkesin, Merva Soluk
    Ustek, Duran
    NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES, 2014, 6 (10) : 505 - 509
  • [37] Expression Of Vascular Endothelial Growth Factor (VEGF) And Vascular Endothelial Growth Factor Receptors (VEGFRs) In Lung Tissue Of Smokers And COPD Patients
    Lee, S. H.
    Lee, E. J.
    Hur, G. Y.
    Lee, S. Y.
    Lee, S. Y.
    Kim, J. H.
    Shin, C.
    Shim, J. J.
    In, K. H.
    Kang, K. H.
    Yoo, S. H.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
  • [38] Upregulation of Endocrine Gland-Derived Vascular Endothelial Growth Factor, But Not Vascular Endothelial Growth Factor in Human Ectopic Endometriotic Tissue
    Lee, Kai-Fai
    Lee, Yin-Lau
    Chan, Rachel W. S.
    Cheong, Ana W. Y.
    Ng, Ernest H. Y.
    Ho, Pak-Chung
    Yeung, William S. B.
    OBSTETRICAL & GYNECOLOGICAL SURVEY, 2010, 65 (08) : 507 - 509
  • [39] Prognostic Value of Tissue Vascular Endothelial Growth Factor Expression in Bladder Cancer: a Meta-analysis
    Huang, Yu-Jing
    Qi, Wei-Xiang
    He, Ai-Na
    Sun, Yuan-Jue
    Shen, Zan
    Yao, Yang
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2013, 14 (02) : 645 - 649
  • [40] Prognostic value of carcinoembryonic antigen and vascular endothelial growth factor tumor tissue content in colorectal cancer
    Ferroni, Patrizia
    Palmirotta, Raffaele
    Spila, Antonella
    Martini, Francesca
    Formica, Vincenzo
    Portarena, Ilaria
    Del Monte, Girolamo
    Buonomo, Oreste
    Roselli, Mario
    Guadagni, Fiorella
    ONCOLOGY, 2006, 71 (3-4) : 176 - 184