Healthcare-Associated SARS-CoV-2 Reinfection after 3 Months with a Phylogenetically Distinct Omicron Variant: A Case Report

被引：2

作者：

Callebaut, Kim ^{[1
]}

Stoefs, Anke ^{[1
]}

Stylemans, Dimitri ^{[2
]}

Soetens, Oriane ^{[1
]}

Crombe, Florence ^{[1
]}

Vancutsem, Ellen ^{[1
]}

Imamura, Hideo ^{[3
]}

Wybo, Ingrid ^{[1
]}

De Geyter, Deborah ^{[1
]}

Pierard, Denis ^{[1
]}

Muyldermans, Astrid ^{[1
]}

Demuyser, Thomas ^{[1
]}

机构：

[1] Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel UZ Brussel, Dept Microbiol & Infect Control, Laarbeeklaan 101, B-1090 Brussels, Belgium

[2] Univ Ziekenhuis Brussel UZ Brussel, Dept Pulmonol, Laarbeeklaan 101, B-1090 Brussels, Belgium

[3] Vrije Univ Brussel VUB, Brussels Interuniv Genom High Throughput Core BRI, Univ Ziekenhuis Brussel UZ Brussel, Laarbeeklaan 101, B-1090 Brussels, Belgium

来源：

VIRUSES-BASEL | 2022年 / 14卷 / 09期

关键词：

COVID-19; reinfection; Omicron; healthcare-associated; COVID-19; INFECTION; OUTBREAK; WORKERS; DISEASE; VIRUS; TIME;

D O I：

10.3390/v14091852

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This case report describes a 60-year-old female patient suffering from systemic sclerosis, for which she received immunomodulatory drugs. Her first SARS-CoV-2-positive nasopharyngeal sample was obtained in the emergency department, on 31 January 2022. Whole genome sequencing confirmed infection with Omicron BA.1.1. Her hospital stay was long and punctuated by many complications, including admission to the intensive care unit. At the beginning of April 2022, she started complaining of increased coughing, for which another SARS-CoV-2 RT-qPCR test was performed. The latter nasopharyngeal swab showed a strongly positive result. To support the theory of healthcare-associated reinfection, whole genome sequencing was performed and confirmed reinfection with Omicron BA.2. Since this patient was one of ten positive cases in this particular ward, a hospital outbreak investigation was performed. Whole genome sequencing data were available for five of these ten patients and showed a cluster of four patients with <= 2 small nucleotide polymorphisms difference.

引用

页数：11

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