Synthesis of Flavones and ?-Benzopyranones Using Mild Sonogashira Coupling and 18-Crown-6 Ether Mediated 6-endo Cyclization

被引：23

作者：

Chuang, Da-Wei ^{[1
]}

El-Shazly, Mohamed ^{[1
,2
]}

Balaji, Barve D. ^{[1
,3
]}

Chung, Yu-Ming ^{[1
]}

Chang, Fang-Rong ^{[1
]}

Wu, Yang-Chang ^{[1
,4
,5
,6
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Ain Shams Univ, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Cairo 11566, Egypt

[3] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan

[4] China Med Univ, Coll Chinese Med, Sch Chinese Med, Taichung 404, Taiwan

[5] China Med Univ Hosp, Nat Med Prod Res Ctr, Taichung 404, Taiwan

[6] China Med Univ Hosp, Ctr Mol Med, Taichung 404, Taiwan

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 24期

关键词：

Synthetic methods; Oxygen heterocycles; Cross-coupling; Cyclization; Michael addition; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; PHASE-II; FLAVOPIRIDOL; CHROMONES; ANALOGS; KETONES; 4H-CHROMEN-4-ONES; COMBINATION; FLAVOXATE;

D O I：

10.1002/ejoc.201200529

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of flavones and ?-benzopyranones has been developed utilizing a mild Sonogashira coupling and 18-crown-6 ether mediated 6-endo cyclization of o-alkynoylphenyl acetates. By using this strategy, flavones and ?-benzopyranones bearing electron-donating groups, halogens, and simple alkyl substituents were synthesized in satisfactory yields.

引用

页码：4533 / 4540

页数：8

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