The Fourth International Workshop on Clinical Transplant Tolerance

被引：23

作者：

Issa, Fadi ^{[1
]}

Strober, Samuel ^{[2
]}

Leventhal, Joseph R. ^{[3
]}

Kawai, Tatsuo ^{[4
]}

Kaufman, Dixon B. ^{[5
]}

Levitsky, Josh ^{[3
]}

Sykes, Megan ^{[6
]}

Mas, Valeria ^{[7
]}

Wood, Kathryn J. ^{[1
]}

Bridges, Nancy ^{[8
]}

Welniak, Lisbeth A. ^{[9
]}

Chandran, Sindhu ^{[10
]}

Madsen, Joren C. ^{[11
,12
]}

Nickerson, Peter ^{[13
]}

Demetris, Anthony J. ^{[14
]}

Lakkis, Fadi G. ^{[15
]}

Thomson, Angus W. ^{[15
]}

机构：

[1] Univ Oxford, Nuffield Dept Surg Sci, Transplantat Res & Immunol Grp, Oxford, England

[2] Stanford Univ, Dept Med, Stanford, CA 94305 USA

[3] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA

[5] Univ Wisconsin, Dept Surg, Madison, WI USA

[6] Columbia Univ, Columbia Ctr Translat Immunol, Dept Microbiol & Immunol, New York, NY USA

[7] Univ Tennessee Hlth Care Sci, Sch Med, Transplant Res Inst, James D Eason Transplant Inst, Memphis, TN USA

[8] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[9] NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA

[10] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[11] Massachusetts Gen Hosp, MGH Transplant Ctr, Boston, MA 02114 USA

[12] Massachusetts Gen Hosp, Dept Surg, Div Cardiac Surg, Boston, MA 02114 USA

[13] Univ Manitoba, Rady Fac Hlth Sci, Winnipeg, MB, Canada

[14] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA

[15] Univ Pittsburgh, Starzl Transplantat Inst, Dept Surg, Pittsburgh, PA 15260 USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2021年 / 21卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

clinical research; practice; clinical trial; immune regulation; immunosuppression; immune modulation; kidney transplantation; nephrology; liver transplantation; hepatology; tolerance; chimerism; clinical; MISMATCHED RENAL-TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; LIVING DONOR KIDNEY; KILLER T-CELLS; ALLOGRAFT TOLERANCE; NKT CELLS; IMMUNOSUPPRESSIVE DRUGS; MIXED CHIMERISM; LIVER; RECIPIENTS;

D O I：

10.1111/ajt.16139

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The International Workshop on Clinical Transplant Tolerance is a biennial meeting that aims to provide an update on the progress of studies of immunosuppression minimization or withdrawal in solid organ transplantation. The Fourth International Workshop on Clinical Tolerance was held in Pittsburgh, Pennsylvania, September 5-6, 2019. This report is a summary of presentations on the status of clinical trials designed to minimize or withdraw immunosuppressive drugs in kidney, liver, and lung transplantation without subsequent evidence of rejection. All protocols had in common the use of donor or recipient cell therapy combined with organ transplantation. The workshop also included presentations of mechanistic studies designed to improve understanding of the cellular and molecular basis of tolerance and to identify potential predictors/biomarkers of tolerance. Strategies to enhance the safety of hematopoietic cell transplantation and to improve patient selection/risk stratification for clinical trials were also discussed.

引用

页码：21 / 31

页数：11

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