The insulin-like growth factor 2 receptor gene Gly1619Arg polymorphism and idiopathic recurrent spontaneous abortion

被引：5

作者：

Pereza, Nina ^{[1
]}

Ostojic, Sasa ^{[1
]}

Volk, Marija ^{[2
]}

Maver, Ales ^{[2
]}

Kapovic, Miljenko ^{[1
]}

Peterlin, Borut ^{[2
]}

机构：

[1] Univ Rijeka, Fac Med, Dept Biol & Med Genet, Rijeka 51000, Croatia

[2] UMC Ljubljana, Inst Med Genet, Dept Obstet & Gynaecol, Ljubljana 1000, Slovenia

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2012年 / 25卷 / 04期

关键词：

Pregnancy; gene polymorphisms; placenta; miscarriage; TROPHOBLAST MIGRATION; EXPRESSION; IGF; PLACENTA;

D O I：

10.3109/14767058.2011.581713

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective. The insulin-like growth factor 2 (IGF2) and its receptor (IGF2R) are important regulators of placental function and fetal growth. Our aim was to investigate the association between IGF2R gene Gly1619Arg G>A polymorphism and recurrent spontaneous abortion (RSA). Methods. Polymerase chain reaction and restriction fragment length polymorphism methods were performed to identify the genotypes in 149 couples with a history of at least three consecutive spontaneous abortions and 149 age-matched, unrelated, and fertile couples. Results. There were no statistically significant differences in genotype or allele frequency among the couples with RSA and healthy controls. Conclusions. We found no evidence that the IGF2R Gly1619Arg variation is associated with RSA.

引用

页码：429 / 431

页数：3

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