Metal-free one-pot three-step process for the direct conversion of aryl alkynes into secondary amines with TfOH/B2(OH)4

被引：12

作者：

Chen, Yongsheng ^{[1
]}

Liu, Sensheng ^{[1
]}

Cui, Peng ^{[1
]}

Zhang, Yin ^{[1
]}

Liu, Qixing ^{[1
]}

Zhou, Haifeng ^{[1
]}

机构：

[1] China Three Gorges Univ, Res Ctr Green Pharmaceut Technol & Proc, Hubei Key Lab Nat Prod Res & Dev, Coll Biol & Pharmaceut Sci, Yichang 443002, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 03期

关键词：

Diboronic acid; Hydration; Aromatic amines; Reduction; INTERMOLECULAR HYDROAMINATION; CATALYZED HYDRATION; REDUCTIVE HYDROAMINATION; TERMINAL ALKYNES; TRANSITION-METAL; CHIRAL ALCOHOLS; ACID; HYDROGENATIONS; COMPLEXES; SOLVENT;

D O I：

10.1016/j.tetlet.2018.12.041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free one-pot synthesis of secondary amines from aryl alkynes via hydration-condensation-reduction three-step process in the presence of TfOH and B-2(OH)(4) has been developed. A series of secondary amines were obtained with good functional group tolerance and satisfied yields. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：327 / 330

页数：4

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