The role of autophagy in Parkinson's disease

被引：17

作者：

Zhang, Lei ^{[1
]}

Dong, Yaru ^{[2
]}

Xu, Xiaoheng ^{[1
]}

Xu, Zhong ^{[1
]}

机构：

[1] Jilin Univ, Hosp 2, Dept Pediat, Changchun 130041, Jilin Province, Peoples R China

[2] Jilin Univ, Hosp 2, Dept Ophthalmol, Changchun 130041, Jilin Province, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 02期

基金：

中国国家自然科学基金;

关键词：

autophagy-lysosome pathway; Parkinson's disease; pathogenesis; review; CHAPERONE-MEDIATED AUTOPHAGY; ALPHA-SYNUCLEIN; CELL-DEATH; CAUSES NEURODEGENERATION; SH-SY5Y CELLS; MITOPHAGY; MUTANT; DEGRADATION; INHIBITION; NEURONS;

D O I：

10.3969/j.issn.1673-5374.2012.02.011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson's disease to highlight the possibility of Parkinson's disease treatment strategies that incorporate autophagy-lysosome pathway modulation.

引用

页码：141 / 145

页数：5

共 46 条

[1] LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model [J].

Alegre-Abarrategui, Javier ;

Christian, Helen ;

Lufino, Michele M. P. ;

Mutihac, Ruxandra ;

Venda, Lara Lourenco ;

Ansorge, Olaf ;

Wade-Martins, Richard .

HUMAN MOLECULAR GENETICS, 2009, 18 (21) :4022-4034

[2]

Anglade P, 1997, HISTOL HISTOPATHOL, V12, P25

[3] Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies [J].

Bedford, Lynn ;

Hay, David ;

Devoy, Anny ;

Paine, Simon ;

Powe, Des G. ;

Seth, Rashmi ;

Gray, Trevor ;

Topham, Ian ;

Fone, Kevin ;

Rezvani, Nooshin ;

Mee, Maureen ;

Soane, Tim ;

Layfield, Robert ;

Sheppard, Paul W. ;

Ebendal, Ted ;

Usoskin, Dmitry ;

Lowe, James ;

Mayer, R. John .

JOURNAL OF NEUROSCIENCE, 2008, 28 (33) :8189-8198

[4]

Bonifati Vincenzo, 2012, Parkinsonism Relat Disord, V18 Suppl 1, pS4, DOI 10.1016/S1353-8020(11)70004-9

[5] The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells [J].

Casarejos, M. J. ;

Solano, R. M. ;

Gomez, A. ;

Perucho, J. ;

de Yebenes, J. G. ;

Mena, M. A. .

NEUROCHEMISTRY INTERNATIONAL, 2011, 58 (04) :512-520

[6] Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species [J].

Chen, Yongqiang ;

McMillan-Ward, Eileen ;

Kong, Jiming ;

Israels, Sara J. ;

Gibson, Spencer B. .

JOURNAL OF CELL SCIENCE, 2007, 120 (23) :4155-4166

[7] Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives [J].

Cheung, Zelda H. ;

Ip, Nancy Y. .

JOURNAL OF NEUROCHEMISTRY, 2011, 118 (03) :317-325

[8] Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy [J].

Choubey, Vinay ;

Safiulina, Dzhamilja ;

Vaarmann, Annika ;

Cagalinec, Michal ;

Wareski, Przemyslaw ;

Kuum, Malle ;

Zharkovsky, Alexander ;

Kaasik, Allen .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (12) :10814-10824

[9] A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease [J].

Cook, Casey ;

Petrucelli, Leonard .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2009, 1792 (07) :664-675

[10] Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy [J].

Cuervo, AM ;

Stefanis, L ;

Fredenburg, R ;

Lansbury, PT ;

Sulzer, D .

SCIENCE, 2004, 305 (5688) :1292-1295

← 1 2 3 4 5 →