May the Force Be With You: The Light and Dark Sides of the Microbiota-Gut-Brain Axis in Neuropsychiatry

被引：218
作者：
Sherwin, Eoin [1 ]
Sandhu, Kiran V. [1 ]
Dinan, Timothy G. [1 ,2 ]
Cryan, John F. [1 ,3 ]
机构：
[1] Univ Coll Cork, APC Microbiome Inst, Cork, Ireland
[2] Univ Coll Cork, Dept Psychiat & Neurobehav Sci, Cork, Ireland
[3] Univ Coll Cork, Dept Anat & Neurosci, Western Gateway Bldg, Cork, Ireland
来源：
CNS DRUGS | 2016年 / 30卷 / 11期
基金：
爱尔兰科学基金会;
关键词：
ANXIETY-LIKE BEHAVIOR; CHAIN FATTY-ACIDS; OLIGOFRUCTOSE PROMOTES SATIETY; MATERNAL IMMUNE ACTIVATION; IRRITABLE-BOWEL-SYNDROME; GLUCAGON-LIKE PEPTIDE-1; PROPIONIC-ACID; DOUBLE-BLIND; FECAL MICROBIOTA; SODIUM-BUTYRATE;
D O I：
10.1007/s40263-016-0370-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The role of the gut microbiota in health and disease is becoming increasingly recognized. The microbiota-gut-brain axis is a bi-directional pathway between the brain and the gastrointestinal system. The bacterial commensals in our gut can signal to the brain through a variety of mechanisms, which are slowly being resolved. These include the vagus nerve, immune mediators and microbial metabolites, which influence central processes such as neurotransmission and behaviour. Dysregulation in the composition of the gut microbiota has been identified in several neuropsychiatric disorders, such as autism, schizophrenia and depression. Moreover, preclinical studies suggest that they may be the driving force behind the behavioural abnormalities observed in these conditions. Understanding how bacterial commensals are involved in regulating brain function may lead to novel strategies for development of microbiota-based therapies for these neuropsychiatric disorders.
引用
收藏
页码：1019 / 1041
页数：23
相关论文
共 192 条
[41]   Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences [J].
Cox, Laura M. ;
Yamanishi, Shingo ;
Sohn, Jiho ;
Alekseyenko, Alexander V. ;
Leung, Jacqueline M. ;
Cho, Ilseung ;
Kim, Sungheon G. ;
Li, Huilin ;
Gao, Zhan ;
Mahana, Douglas ;
Rodriguez, Jorge G. Zarate ;
Rogers, Arlin B. ;
Robine, Nicolas ;
Loke, P'ng ;
Blaser, Martin J. .
CELL, 2014, 158 (04) :705-721
[42]   Absence of the gut microbiota enhances anxiety-like behavior and neuroendocrine response to acute stress in rats [J].
Crumeyrolle-Arias, Michele ;
Jaglin, Mathilde ;
Bruneau, Aurelia ;
Vancassel, Sylvie ;
Cardona, Ana ;
Dauge, Valerie ;
Naudon, Laurent ;
Rabot, Sylvie .
PSYCHONEUROENDOCRINOLOGY, 2014, 42 :207-217
[43]   GUT MICROBIOTA Microbiota and neuroimmune signalling-Metchnikoff to microglia [J].
Cryan, John F. ;
Dinan, Timothy G. .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2015, 12 (09) :495-496
[44]   Probiotics Improve Inflammation-Associated Sickness Behavior by Altering Communication between the Peripheral Immune System and the Brain [J].
D'Mello, Charlotte ;
Ronaghan, Natalie ;
Zaheer, Raza ;
Dicay, Michael ;
Le, Tai ;
MacNaughton, Wallace K. ;
Surrette, Michael G. ;
Swain, Mark G. .
JOURNAL OF NEUROSCIENCE, 2015, 35 (30) :10821-10830
[45]   Inflammation-associated depression: From serotonin to kynurenine [J].
Dantzer, Robert ;
O'Connor, Jason C. ;
Lawson, Marcus A. ;
Kelley, Keith W. .
PSYCHONEUROENDOCRINOLOGY, 2011, 36 (03) :426-436
[46]   Chronic Functional Bowel Syndrome Enhances Gut-Brain Axis Dysfunction, Neuroinflammation, Cognitive Impairment, and Vulnerability to Dementia [J].
Daulatzai, Mak Adam .
NEUROCHEMICAL RESEARCH, 2014, 39 (04) :624-644
[47]   Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat [J].
Davey, K. J. ;
Cotter, P. D. ;
O'Sullivan, O. ;
Crispie, F. ;
Dinan, T. G. ;
Cryan, J. F. ;
O'Mahony, S. M. .
TRANSLATIONAL PSYCHIATRY, 2013, 3 :e309-e309
[48]   Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters [J].
Davey, Kieran J. ;
O'Mahony, Siobhain M. ;
Schellekens, Harriet ;
O'Sullivan, Orla ;
Bienenstock, John ;
Cotter, Paul D. ;
Dinan, Timothy G. ;
Cryan, John F. .
PSYCHOPHARMACOLOGY, 2012, 221 (01) :155-169
[49]   Microbiota and host determinants of behavioural phenotype in maternally separated mice [J].
De Palma, G. ;
Blennerhassett, P. ;
Lu, J. ;
Deng, Y. ;
Park, A. J. ;
Green, W. ;
Denou, E. ;
Silva, M. A. ;
Santacruz, A. ;
Sanz, Y. ;
Surette, M. G. ;
Verdu, E. F. ;
Collins, S. M. ;
Bercik, P. .
NATURE COMMUNICATIONS, 2015, 6
[50]   Altered gut microbiota and activity in a murine model of autism spectrum disorders [J].
de Theije, Caroline G. M. ;
Wopereis, Harm ;
Ramadan, Mohamed ;
van Eijndthoven, Tiemen ;
Lambert, Jolanda ;
Knol, Jan ;
Garssen, Johan ;
Kraneveld, Aletta D. ;
Oozeer, Raish .
BRAIN BEHAVIOR AND IMMUNITY, 2014, 37 :197-206
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