May the Force Be With You: The Light and Dark Sides of the Microbiota-Gut-Brain Axis in Neuropsychiatry

被引：213
作者：
Sherwin, Eoin [1 ]
Sandhu, Kiran V. [1 ]
Dinan, Timothy G. [1 ,2 ]
Cryan, John F. [1 ,3 ]
机构：
[1] Univ Coll Cork, APC Microbiome Inst, Cork, Ireland
[2] Univ Coll Cork, Dept Psychiat & Neurobehav Sci, Cork, Ireland
[3] Univ Coll Cork, Dept Anat & Neurosci, Western Gateway Bldg, Cork, Ireland
来源：
CNS DRUGS | 2016年 / 30卷 / 11期
基金：
爱尔兰科学基金会;
关键词：
ANXIETY-LIKE BEHAVIOR; CHAIN FATTY-ACIDS; OLIGOFRUCTOSE PROMOTES SATIETY; MATERNAL IMMUNE ACTIVATION; IRRITABLE-BOWEL-SYNDROME; GLUCAGON-LIKE PEPTIDE-1; PROPIONIC-ACID; DOUBLE-BLIND; FECAL MICROBIOTA; SODIUM-BUTYRATE;
D O I：
10.1007/s40263-016-0370-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The role of the gut microbiota in health and disease is becoming increasingly recognized. The microbiota-gut-brain axis is a bi-directional pathway between the brain and the gastrointestinal system. The bacterial commensals in our gut can signal to the brain through a variety of mechanisms, which are slowly being resolved. These include the vagus nerve, immune mediators and microbial metabolites, which influence central processes such as neurotransmission and behaviour. Dysregulation in the composition of the gut microbiota has been identified in several neuropsychiatric disorders, such as autism, schizophrenia and depression. Moreover, preclinical studies suggest that they may be the driving force behind the behavioural abnormalities observed in these conditions. Understanding how bacterial commensals are involved in regulating brain function may lead to novel strategies for development of microbiota-based therapies for these neuropsychiatric disorders.
引用
收藏
页码：1019 / 1041
页数：23
相关论文
共 192 条
[1]   Antibiotic-induced dysbiosis alters host-bacterial interactions and leads to colonic sensory and motor changes in mice [J].
Aguilera, M. ;
Cerda-Cuellar, M. ;
Martinez, V. .
GUT MICROBES, 2015, 6 (01) :10-23
[2]   Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice [J].
Ait-Belgnaoui, A. ;
Colom, A. ;
Braniste, V. ;
Ramalho, L. ;
Marrot, A. ;
Cartier, C. ;
Houdeau, E. ;
Theodorou, V. ;
Tompkins, T. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2014, 26 (04) :510-520
[3]   Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats [J].
Ait-Belgnaoui, Afifa ;
Durand, Henri ;
Cartier, Christel ;
Chaumaz, Gilles ;
Eutamene, Helene ;
Ferrier, Laurent ;
Houdeau, Eric ;
Fioramonti, Jean ;
Bueno, Lionel ;
Theodorou, Vassilia .
PSYCHONEUROENDOCRINOLOGY, 2012, 37 (11) :1885-1895
[4]   Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial [J].
Akkasheh, Ghodarz ;
Kashani-Poor, Zahra ;
Tajabadi-Ebrahimi, Maryam ;
Jafari, Parvaneh ;
Akbari, Hossein ;
Taghizadeh, Mohsen ;
Memarzadeh, Mohammad Reza ;
Asemi, Zatollah ;
Esmaillzadeh, Ahmad .
NUTRITION, 2016, 32 (03) :315-320
[5]   Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis [J].
Albaugh, V. L. ;
Judson, J. G. ;
She, P. ;
Lang, C. H. ;
Maresca, K. P. ;
Joyal, J. L. ;
Lynch, C. J. .
MOLECULAR PSYCHIATRY, 2011, 16 (05) :569-581
[6]   Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice [J].
Asano, Yasunari ;
Hiramoto, Tetsuya ;
Nishino, Ryo ;
Aiba, Yuji ;
Kimura, Tae ;
Yoshihara, Kazufumi ;
Koga, Yasuhiro ;
Sudo, Nobuyuki .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 303 (11) :G1288-G1295
[7]   Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders [J].
Atladottir, Hjordis O. ;
Thorsen, Poul ;
Ostergaard, Lars ;
Schendel, Diana E. ;
Lemcke, Sanne ;
Abdallah, Morsi ;
Parner, Erik T. .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2010, 40 (12) :1423-1430
[8]   The gut microbiota as an environmental factor that regulates fat storage [J].
Bäckhed, F ;
Ding, H ;
Wang, T ;
Hooper, LV ;
Koh, GY ;
Nagy, A ;
Semenkovich, CF ;
Gordon, JI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (44) :15718-15723
[9]   Mechanisms underlying the resistance to diet-induced obesity in germ-free mice [J].
Backhed, Fredrik ;
Manchester, Jill K. ;
Semenkovich, Clay F. ;
Gordon, Jeffrey I. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :979-984
[10]   Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation [J].
Bailey, Michael T. ;
Dowd, Scot E. ;
Galley, Jeffrey D. ;
Hufnagle, Amy R. ;
Allen, Rebecca G. ;
Lyte, Mark .
BRAIN BEHAVIOR AND IMMUNITY, 2011, 25 (03) :397-407
12345678910