Diet-Based Strategies for Cancer Chemoprevention: The Role of Combination Regimens Using Dietary Bioactive Components

被引：53

作者：

DiMarco-Crook, Christina ^{[1
]}

Xiao, Hang ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA

来源：

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 6 | 2015年 / 6卷

基金：

美国国家卫生研究院;

关键词：

dietary bioactive components; cancer chemoprevention; combination; synergy; whole foods; colorectal cancer; prostate cancer; breast cancer; lung cancer; INDUCED COLON CARCINOGENESIS; ABERRANT CRYPT FOCI; PROSTATE-CANCER; CELL-PROLIFERATION; GENE-EXPRESSION; VITAMIN-E; RAT COLON; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; LUNG ADENOCARCINOMA;

D O I：

10.1146/annurev-food-081114-110833

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Chemopreventive agents that the general population can consume for prolonged periods of time with minimal risk of any side effects are of great interest to all in search of a solution to the pervasive incidence of cancer. Dietary bioactive components have been found to modulate many deregulated molecular pathways associated with the initiation and progression of different types of cancer. Combination regimens with dietary bioactive components are a promising strategy for cancer chemoprevention because they may offer enhanced protective effects against cancer development but cause little or no adverse effects. This article provides an overview of studies examining the combination of dietary bioactive components for the chemoprevention of major types of cancer. A better understanding of existing research on the combination of dietary bioactive components will provide an important basis for the rational design of future combination studies and the successful development of cancer chemoprevention strategies.

引用

页码：505 / 526

页数：22

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