Nuclear beta-catenin overexpression in metastatic sentinel lymph node is associated with synchronous liver metastasis in colorectal cancer

被引:20
作者
Cheng, Hongxia [1 ]
Liang, Hui [2 ]
Qin, Yejun [1 ]
Liu, Ying [1 ]
机构
[1] Shandong Univ, Prov Hosp, Dept Pathol, Jinan 250021, Shandong, Peoples R China
[2] Shandong Univ, Qianfoshan Hosp, Dept Otolaryngol, Jinan 250014, Shandong, Peoples R China
关键词
Beta-catenin; Colorectal cancer; Liver metastasis; Sentinel lymph node; RISK-FACTORS; CLINICAL-SIGNIFICANCE; INVASION FRONT; YOUNG-PATIENTS; STEM-CELLS; EXPRESSION; BIOPSY; ADHESION; COLON; LYMPHADENECTOMY;
D O I
10.1186/1746-1596-6-109
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Background: Beta-catenin, a component of the Wingless/Wnt signaling pathway, can activate target genes linking with the adenomatous polyposis coli (APC) gene in colorectal cancer. The purpose of this study is to investigate whether nuclear beta-catenin overexpression in metastatic sentinel lymph node(s) [SLN(s)] is associated with synchronous liver metastasis. Methods: Clinicopathological data from 355 patients (93 cases with liver metastasis and 262 cases without liver metastasis) were reviewed. Beta-catenin expression in metastatic SLN(s) and liver metastatic lesions was examined by immunohistochemistry. The association of nuclear beta-catenin expression in metastatic SLN(s) and liver metastatic lesions was evaluated, and the relationship between nuclear beta-catenin expression and clinicopathological characteristics was analyzed. Finally, univariate and logistic multivariate regression analyses were adopted to discriminate the risk factors of liver metastasis. Results: Nuclear beta-catenin overexpression in metastatic SLN(s) was observed in 70 patients with liver metastasis and 31 patients without liver metastasis (75.3% vs. 11.8%; P < 0.001). Nuclear beta-catenin expression was noted in all the metastatic lesions. Spearman rank correlation analysis demonstrated that nuclear beta-catenin expression in metastatic SLN(s) had a positive correlation with that in metastatic lesions (r = 0.425, P < 0.001). Univariate and multivariate analyses indicated that nuclear beta-catenin overexpression in metastatic SLN(s) correlated with liver metastasis. Conclusions: Nuclear beta-catenin overexpression in metastatic SLN(s) is strongly associated with liver metastasis and may contribute to predict liver metastasis.
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页数:8
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