The dilute-lethal (d(l)) gene attacks a Ca2+ store in the dendritic spine of Purkinje cells in mice

被引：133

作者：

Takagishi, Y ^{[1
]}

Oda, S ^{[1
]}

Hayasaka, S ^{[1
]}

DekkerOhno, K ^{[1
]}

Shikata, T ^{[1
]}

Inouye, M ^{[1
]}

Yamamura, H ^{[1
]}

机构：

[1] NAGOYA UNIV,GRAD SCH AGR SCI,NAGOYA,AICHI 46401,JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 215卷 / 03期

关键词：

dilute-lethal; cerebellum; Purkinje cells; recessive mutation; smooth endoplasmic reticulum; Ca2+; intracellular Ca2+ signaling;

D O I：

10.1016/S0304-3940(96)12967-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The absence of smooth endoplasmic reticulum (SER) in the dendritic spine of Purkinje cells was found in dilute-lethal (d(l)) mouse cerebella as detected by immunohistochemistry using anti-inositol 1,4,5-triphosphate receptor antibody and electron microscopy. Since SER in the spine has been suggested to play a crucial role for synaptic regulation as an intracellular Ca2+ store (for reviews, see [Miller, R.J., Frog. Neurobiol., 37 (1991) 255-285; Simpson, P.B., Challiss, R.A.J. and Nahorski, S.R., Trends Neurosci., 18 (1995) 299-306]), a neurological defect, characterized by clonic convulsions with opisthotonus and ataxia, in the dilute-lethal mouse with homozygous trait may be attributable to the absence of SER in the dendritic spine of Purkinje cells.

引用

页码：169 / 172

页数：4

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