ELM-the database of eukaryotic linear motifs

被引：252

作者：

Dinkel, Holger ^{[1
]}

Michael, Sushama ^{[1
]}

Weatheritt, Robert J. ^{[1
]}

Davey, Norman E. ^{[1
]}

Van Roey, Kim ^{[1
]}

Altenberg, Brigitte ^{[1
]}

Toedt, Grischa ^{[1
]}

Uyar, Bora ^{[1
]}

Seiler, Markus ^{[1
]}

Budd, Aidan ^{[1
]}

Joedicke, Lisa ^{[1
]}

Dammert, Marcel A. ^{[1
]}

Schroeter, Christian ^{[1
]}

Hammer, Maria ^{[1
]}

Schmidt, Tobias ^{[1
]}

Jehl, Peter ^{[1
]}

McGuigan, Caroline ^{[1
]}

Dymecka, Magdalena ^{[2
,3
]}

Chica, Claudia ^{[4
]}

Luck, Katja ^{[5
]}

Via, Allegra ^{[6
]}

Chatr-Aryamontri, Andrew ^{[7
]}

Haslam, Niall ^{[8
]}

Grebnev, Gleb ^{[8
]}

Edwards, Richard J. ^{[9
]}

Steinmetz, Michel O. ^{[10
]}

Meiselbach, Heike ^{[11
]}

Diella, Francesca ^{[1
,12
]}

Gibson, Toby J. ^{[1
]}

机构：

[1] European Mol Biol Lab, Heidelberg, Germany

[2] M Sklodowska Curie Canc Ctr, Lab Bioinformat & Syst Biol, PL-02781 Warsaw, Poland

[3] Inst Oncol, PL-02781 Warsaw, Poland

[4] CEA, Genoscope Inst Genom, F-91057 Evry, France

[5] UDS, CNRS, Inst Rech Ecole Biotechnol Strasbourg, Grp Oncoproteins,Unite UMR 7242, F-67412 Illkirch Graffenstaden, France

[6] Univ Roma La Sapienza, Dept Phys, Biocomp Grp, I-00185 Rome, Italy

[7] Univ Edinburgh, Sch Biol Sci, Edinburgh EH9 3JR, Midlothian, Scotland

[8] Univ Coll Dublin, Sch Med & Med Sci, Dublin 2, Ireland

[9] Univ Southampton, Inst Life Sci, Ctr Biol Sci, Southampton SO9 5NH, Hants, England

[10] Paul Scherrer Inst, Biomol Res, CH-5232 Villigen, Switzerland

[11] Univ Erlangen Nurnberg, Inst Biochem, D-91054 Erlangen, Germany

[12] Mol Hlth GmbH, D-69115 Heidelberg, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / D1期

基金：

英国生物技术与生命科学研究理事会; 爱尔兰科学基金会; 瑞士国家科学基金会;

关键词：

D O I：

10.1093/nar/gkr1064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our understanding of motifs is surprisingly limited, largely as a result of the difficulty of discovery, both experimentally and computationally. The Eukaryotic Linear Motif (ELM) resource at http://elm.eu.org provides the biological community with a comprehensive database of known experimentally validated motifs, and an exploratory tool to discover putative linear motifs in user-submitted protein sequences. The current update of the ELM database comprises 1800 annotated motif instances representing 170 distinct functional classes, including approximately 500 novel instances and 24 novel classes. Several older motif class entries have been also revisited, improving annotation and adding novel instances. Furthermore, addition of full-text search capabilities, an enhanced interface and simplified batch download has improved the overall accessibility of the ELM data. The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances.

引用

页码：D242 / D251

页数：10

共 42 条

[11] Understanding eukaryotic linear motifs and their role in cell signaling and regulation [J].