Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target

被引：448

作者：

Shuaib, Ashfaq ^{[1
]}

Butcher, Ken ^{[1
]}

Mohammad, Askar A. ^{[1
]}

Saqqur, Maher ^{[1
]}

Liebeskind, David S. ^{[2
]}

机构：

[1] Univ Alberta, Dept Med, Div Neurol, Edmonton, AB T6G 2B7, Canada

[2] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA

来源：

LANCET NEUROLOGY | 2011年 / 10卷 / 10期

关键词：

CEREBRAL-ARTERY OCCLUSION; EVALUATION TRIAL EPITHET; HYPERVOLEMIC HEMODILUTION; CT ANGIOGRAPHY; SPHENOPALATINE GANGLION; ELECTRICAL-STIMULATION; DIFFUSION MISMATCH; BRAIN-DAMAGE; H; FLOW;

D O I：

10.1016/S1474-4422(11)70195-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ischaemic stroke results from acute arterial occlusion leading to focal hypoperfusion. Thrombolysis is the only proven treatment. Advanced neuroimaging techniques allow a detailed assessment of the cerebral circulation in patients with acute stroke, and provide information about the status of collateral vessels and collateral blood flow, which could attenuate the effects of arterial occlusion. Imaging of the brain and vessels has shown that collateral flow can sustain brain tissue for hours after the occlusion of major arteries to the brain, and the augmentation or maintenance of collateral flow is therefore a potential therapeutic target. Several interventions that might augment collateral blood flow are being investigated.

引用

页码：909 / 921

页数：13

共 94 条

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