Expression of Hepatocyte Growth Factor/c-met by RT-PCR in Meningiomas

被引:1
作者
Kim, Na Rae [1 ]
Chae, Yang Seok [2 ]
Lim, Weon Jeong [3 ]
Cho, Seong Jin [4 ]
机构
[1] Gachon Univ, Gil Hosp, Dept Pathol, Inchon, South Korea
[2] Korea Univ, Coll Med, Anam Hosp, Dept Pathol, Seoul 136705, South Korea
[3] Ewha Womans Univ, Sch Med, Mokdong Hosp, Dept Neurochiatry, Seoul, South Korea
[4] Hallym Univ, Coll Med, Kangdong Sacred Heart Hosp, Dept Pathol, Seoul 134701, South Korea
关键词
Hepatocyte growth factor; c-met; Meningioma; Neoplasm recurrence; local; Reverse transcription polymerase chain reaction; FACTOR SCATTER FACTOR; FACTOR/SCATTER FACTOR HGF/SF; RECEPTOR C-MET; PREDICT RECURRENCE; OVEREXPRESSION; MOTILITY; GLIOMAS; BENIGN; POTENT; MIB-1;
D O I
10.4132/KoreanJPathol.2011.45.5.463
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Background: Hepatocyte growth factor (HGF) is a potent mitogenic cytokine. C-met protein, which is known to be the HGF receptor has transmembrane tyrosine kinase activity and is encoded by the c-met oncogene. The HGF/c-met signaling pathway may play various roles in the carcinogenesis of various organs. Methods: We examined HGF and c-met mRNA expression by utilizing reverse transcription polymerase chain reaction on 40 surgically resected intracranial meningiomas (25 benign, 10 atypical, and 5 anaplastic cases). Results: An HGF overexpression was detected in 28%, 50%, and 80% of the benign, atypical and anaplastic meningiomas, respectively; a high expression of HGF or the coexpression of HGF/c-met was detected in the high grade meningiomas (the atypical and anaplastic cases, p = 0.046, p = 0.014). An HGF expression was statistically significant in the recurrent meningiomas (p = 0.003), and HGF expression was significantly lower than c-met mRNA expression in benign meningiomas (p = 0.034). Conclusions: There was no correlation between histologic subtypes and HGF/c-met expression. Determination of HGF expression can be used as a molecular predictor for recurrence of meningioimas. These results suggest that HGF and c-met expression in meningiomas may be associated with anaplastic progression.
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收藏
页码:463 / 468
页数:6
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