Alternative Splicing and Isoforms: From Mechanisms to Diseases

被引：80

作者：

Liu, Qi ^{[1
]}

Fang, Leiming ^{[1
]}

Wu, Chengjun ^{[1
]}

机构：

[1] Dalian Univ Technol, Sch Biomed Engn, Dalian 116024, Peoples R China

来源：

GENES | 2022年 / 13卷 / 03期

基金：

中国国家自然科学基金;

关键词：

alternative splicing; splicing factors; diseases; drugs; CYCLIN D1B; BREAST-CANCER; LEPTIN; SPLICEOSOME; EXPRESSION; MODULATE; TARGET; MOUSE;

D O I：

10.3390/genes13030401

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Alternative splicing of pre-mRNA is a key mechanism for increasing the complexity of proteins in humans, causing a diversity of expression of transcriptomes and proteomes in a tissue-specific manner. Alternative splicing is regulated by a variety of splicing factors. However, the changes and errors of splicing regulation caused by splicing factors are strongly related to many diseases, something which represents one of this study's main interests. Further understanding of alternative splicing regulation mediated by cellular factors is also a prospective choice to develop specific drugs for targeting the dynamic RNA splicing process. In this review, we firstly concluded the basic principle of alternative splicing. Afterwards, we showed how splicing isoforms affect physiological activities through specific disease examples. Finally, the available treatment methods relative to adjusting splicing activities have been summarized.

引用

页数：11

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