Synthesis and In Vivo Fate of Zwitterionic Near-Infrared Fluorophores

被引：307

作者：

Choi, Hak Soo ^{[2
,3
]}

Nasr, Khaled ^{[2
,3
]}

Alyabyev, Sergey ^{[1
]}

Feith, Dina ^{[2
,3
]}

Lee, Jeong Heon ^{[2
,3
]}

Kim, Soon Hee ^{[2
,3
,4
]}

Ashitate, Yoshitomo ^{[2
,3
]}

Hyun, Hoon ^{[2
,3
]}

Patonay, Gabor ^{[1
]}

Strekowski, Lucjan ^{[1
]}

Henary, Maged ^{[1
]}

Frangioni, John V. ^{[2
,3
]}

机构：

[1] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA

[2] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA

[3] Beth Israel Deaconess Med Ctr, Dept Med, Div Hematol Oncol, Boston, MA 02215 USA

[4] Chonbuk Natl Univ, WCU Dept BIN Fus Technol, Jeonju 561756, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 28期

基金：

美国国家卫生研究院;

关键词：

biodistribution; clearance; fluorescent probes; imaging agents; near-infrared fluorophores; HEPTAMETHINE CYANINE DYES; EXTRAHEPATIC BILE-DUCTS; QUANTUM DOTS; NANOPARTICLES; FUNDAMENTALS;

D O I：

10.1002/anie.201102459

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To address two fundamental and unsolved problems in optical imaging (nonspecific uptake of near-infrared fluorophores by normal tissues and organs and incomplete elimination of unbound targeted fluorophores from the body), novel zwitterionic near-infrared fluorophores (e.g., ZW800-1) were synthesized and their performance compared in vivo to conventional molecules (e.g., ICG) as a function of charge, charge distribution, and hydrophobicity (see picture). Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6258 / 6263

页数：6

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