Mediastinal lymph nodes in patients with non-small cell lung cancer - Preliminary experience with diffusion-weighted MR imaging

Objectives: The purpose of our study was to describe our preliminary experience of evaluating mediastinal lymph node metastases with diffusion-weighted magnetic resonance (MR) imaging in patients with non-small cell lung cancer. Materials and Methods: Forty-two consecutive patients with non-small cell lung cancer underwent preoperative diffusion-weighted MR imaging using a non-breath-hold short inversion time inversion recovery-echo planar imaging sequence with a high b value of 1000 s/mm(2). An experienced thoracic radiologist prospectively evaluated each study for mediastinal lymph node metastases on a per-patient basis. On diffusion-weighted MR imaging, mediastinal lymph node metastasis was defined as a focus of low signal intensity at the site of a visible lymph node on corresponding T2-weighted image. The MR results were correlated with histopathologic findings. Results: Diffusion-weighted MR imaging demonstrated mediastinal lymph node metastasis in 4 (80%) of 5 patients with pathologically proven metastasis and accurately identified 36 (97%) of 37 patients without mediastinal lymph node metastasis. Thus, 40 (95%) of 42 patients were accurately diagnosed. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of diffusion-weighted MR imaging for mediastinal lymph node metastasis were 80%, 97/o, 80%, 97%, and 95%, respectively. Conclusions: Our preliminary results show that diffusion-weighted MR imaging has a high negative predictive value for excluding mediastinal lymph node metastases from non-small cell lung cancer and has the potential to be a reliable alternative non-invasive imaging method for the preoperative staging of mediastinal lymph node in patients with non-small cell lung cancer.