Humanized HO-1 BAC transgenic mice: a new model for the study of HO-1 gene regulation

被引：1

作者：

Salom, Miguel G. ^{[1
]}

Bonacasa, Barbara ^{[1
]}

机构：

[1] Univ Murcia, Fac Med, Dept Physiol, E-30100 Murcia, Spain

来源：

KIDNEY INTERNATIONAL | 2012年 / 82卷 / 03期

关键词：

HEME; EXPRESSION; INJURY;

D O I：

10.1038/ki.2012.149

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Heme oxygenase-1 (HO-1) is a ubiquitous inducible stress-response enzyme that plays a central role in tissue homeostasis, in protection against oxidative stress, and in the pathogenesis of disease. Kim et al. report a novel transgenic mouse that lacks the endogenous HO-1 gene but contains the human HO-1 gene with all its regulatory elements. These transgenic animals overexpress HO-1 in basal conditions but maintain HO-1 inducibility, protecting the kidney against glycerol-and cisplatin-induced nephrotoxicity. Kidney International (2012) 82, 253-255. doi:10.1038/ki.2012.149

引用

页码：253 / 255

页数：3

共 9 条

[1] In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice [J].

Kim, Junghyun ;

Zarjou, Abolfazl ;

Traylor, Amie M. ;

Bolisetty, Subhashini ;

Jaimes, Edgar A. ;

Hull, Travis D. ;

George, James F. ;

Mikhail, Fady M. ;

Agarwal, Anupam .

KIDNEY INTERNATIONAL, 2012, 82 (03) :278-291

[2] Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia [J].

Minamino, T ;

Christou, H ;

Hsieh, CM ;

Liu, YX ;

Dhawan, V ;

Abraham, NG ;

Perrella, MA ;

Mitsialis, SA ;

Kourembanas, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) :8798-8803

[3] Heme oxygenase 1 is required for mammalian iron reutilization [J].

Poss, KD ;

Tonegawa, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10919-10924

[4] Reduced stress defense in heme oxygenase 1-deficient cells [J].

Poss, KD ;

Tonegawa, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (20) :10925-10930

[5] Mechanisms of HO-1 mediated attenuation of renal immune injury: a gene profiling study [J].

Pu Duann ;

Lianos, Elias A. .

TRANSLATIONAL RESEARCH, 2011, 158 (04) :249-261

[6] Heme Oxygenase-1/Carbon Monoxide From Metabolism to Molecular Therapy [J].

Ryter, Stefan W. ;

Choi, Augustine M. K. .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2009, 41 (03) :251-260

[7] The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury [J].

Sikorski, EM ;

Hock, T ;

Hill-Kapturczak, N ;

Agarwal, A .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 286 (03) :F425-F441

[8] Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency [J].

Yachie, A ;

Niida, Y ;

Wada, T ;

Igarashi, N ;

Kaneda, H ;

Toma, T ;

Ohta, K ;

Kasahara, Y ;

Koizumi, S .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (01) :129-135

[9] Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice [J].

Yet, SF ;

Tian, R ;

Layne, MD ;

Wang, ZY ;

Maemura, K ;

Solovyeva, M ;

Ith, B ;

Melo, LG ;

Zhang, LN ;

Ingwall, JS ;

Dzau, VJ ;

Lee, ME ;

Perrella, MA .

CIRCULATION RESEARCH, 2001, 89 (02) :168-173

← 1 →