The Ganzi-Yushu-Xianshuihe Fault Zone (GYXFZ) is a typical active strike-slip fault that has triggered many large historic earthquakes, including the 2010 M-w 6.9 Yushu earthquake in the central Tibetan Plateau. This fault zone extends for ca. 800 km from the central Tibetan Plateau to its southeastern margin and varies in trend from WNW-ESE in the northwestern segment of the fault zone to NNW-SSE in the southeastern segment, having the geometry of an arc projecting northeastwards. In this study, we present evidence for the systematical sinistral deflection and/or offset of the Yangtze River and its branch stream channels and valleys along the GYXFZ. Topographic analysis of three-dimensional (3D) perspective images constructed using digital elevation model (DEM) data, 0.5 m-resolution WorldView and GeoEye images, and 15 m-resolution Landsat-Enhanced Thematic Mapper (ETM+) images, together with analysis of geological structures, reveals the following: (i) the main river channels and valleys of the Yangtze River drainage system show systematic sinistral deflections and/or offsets along the GYXFZ; (ii) various amounts of sinistral offset have accumulated on the tributary stream channels, valleys, and gullies of the Yangtze River along the fault, with a linear relation, D = aL, between the upstream length L from the deflected point and the offset amount D with a certain coefficient a; (iii) the maximum amount of sinistral offset is up to ca. 60 km, which was accumulated in the past 13-5 Ma; and (iv) the long-term average strike-slip rate is ca. 4.6-12 mm/year. Geological and geomorphic evidence, combined with geophysical data, demonstrates that the GYXFZ is currently active as one of the major seismogenic faults in the Tibetan Plateau, dominated by left-lateral strike-slip motion. Our findings supply important evidence for the tectonic evolution of strike-slip faults in the Tibetan Plateau since the Eurasia-India continental collision. (C) 2015 Elsevier Ltd. All rights reserved.