Repurposing CD8+T cell immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?

被引：13

作者：

Gujar, Shashi ^{[1
,2
,3
,4
]}

Pol, Jonathan G. ^{[5
,6
,7
]}

Kim, Youra ^{[1
]}

Kroemer, Guido ^{[5
,6
,7
,8
,9
,10
,11
]}

机构：

[1] Dalhousie Univ, Dept Pathol, Halifax, NS, Canada

[2] Dalhousie Univ, Dept Microbiol & Immunol, Halifax, NS, Canada

[3] Dalhousie Univ, Dept Biol, Halifax, NS, Canada

[4] Beatrice Hunter Canc Res Inst, Halifax, NS, Canada

[5] Univ Paris, Ctr Rech Cordeliers, Equipe Labellisee Ligue Natl Canc 11, Sorbonne Univ,INSERM U1138, Paris, France

[6] Gustave Roussy Canc Campus, Villejuif, France

[7] Gustave Roussy Canc Campus, Metabol & Cell Biol Platforms, Villejuif, France

[8] Inst Univ France, Paris, France

[9] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[10] Chinese Acad Med Sci, Suzhou Inst Syst Med, Suzhou, Peoples R China

[11] Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden

来源：

ONCOIMMUNOLOGY | 2020年 / 9卷 / 01期

基金：

欧盟地平线“2020”; 加拿大健康研究院;

关键词：

SARS-CoV-2; antiviral immunity; cancer immunotherapy; antigen spreading; CD8(+)T cell epitopes;

D O I：

10.1080/2162402X.2020.1794424

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The COVID-19 pandemic has afflicted most countries on the planet. As a result, immunity against SARS-CoV-2, induced via natural infections or imminent vaccinations, is expected to develop in a large fraction of the global population. Here, we propose to exploit SARS-CoV-2-specific CD8(+)T cells for cancer immunotherapy strategies.

引用

页数：4

共 19 条

[1] T Lymphocyte-Based Cancer Immunotherapeutics [J].

Borrie, Adrienne E. ;

Vareki, Saman Maleki .

BIOLOGY OF T CELLS, PT A, 2018, 341 :201-276

[2] Clinical and immunological features of severe and moderate coronavirus disease 2019 [J].

Chen, Guang ;

Wu, Di ;

Guo, Wei ;

Cao, Yong ;

Huang, Da ;

Wang, Hongwu ;

Wang, Tao ;

Zhang, Xiaoyun ;

Chen, Huilong ;

Yu, Haijing ;

Zhang, Xiaoping ;

Zhang, Minxia ;

Wu, Shiji ;

Song, Jianxin ;

Chen, Tao ;

Han, Meifang ;

Li, Shusheng ;

Luo, Xiaoping ;

Zhao, Jianping ;

Ning, Qin .

JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (05) :2620-2629

[3] The hallmarks of successful anticancer immunotherapy [J].

Galluzzi, Lorenzo ;

Chan, Timothy A. ;

Kroemer, Guido ;

Wolchok, Jedd D. ;

Lopez-Soto, Alejandro .

SCIENCE TRANSLATIONAL MEDICINE, 2018, 10 (459)

[4] Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals [J].

Grifoni, Alba ;

Weiskopf, Daniela ;

Ramirez, Sydney, I ;

Mateus, Jose ;

Dan, Jennifer M. ;

Moderbacher, Carolyn Rydyznski ;

Rawlings, Stephen A. ;

Sutherland, Aaron ;

Premkumar, Lakshmanane ;

Jadi, Ramesh S. ;

Marrama, Daniel ;

de Silva, Aravinda M. ;

Frazier, April ;

Carlin, Aaron F. ;

Greenbaum, Jason A. ;

Peters, Bjoern ;

Krammer, Florian ;

Smith, Davey M. ;

Crotty, Shane ;

Sette, Alessandro .

CELL, 2020, 181 (07) :1489-+

[5]

Gujar Shashi, 2019, Cell, V176, P1240, DOI 10.1016/j.cell.2019.01.051

[6] Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies [J].

Gujar, Shashi ;

Pol, Jonathan G. ;

Kim, Youra ;

Lee, Patrick W. ;

Kroemer, Guido .

TRENDS IN IMMUNOLOGY, 2018, 39 (03) :209-221

[7] History of oncolytic viruses: Genesis to genetic engineering [J].

Kelly, Elizabeth ;

Russell, Stephen J. .

MOLECULAR THERAPY, 2007, 15 (04) :651-659

[8] Repurposing infectious disease vaccines for intratumoral immunotherapy [J].

Melero, Ignacio ;

Gato, Maria ;

Shekarian, Tala ;

Aznar, Angela ;

Valsesia-Wittmann, Sandrine ;

Caux, Christophe ;

Etxeberrria, Inaki ;

Teijeira, Alvaro ;

Marabelle, Aurelien .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (01)

[9] Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy [J].

Millar, David G. ;

Ramjiawan, Rakesh R. ;

Kawaguchi, Kosuke ;

Gupta, Nisha ;

Chen, Jiang ;

Zhang, Songfa ;

Nojiri, Takashi ;

Ho, William W. ;

Aoki, Shuichi ;

Jung, Keehoon ;

Chen, Ivy ;

Shi, Feng ;

Heather, James M. ;

Shigeta, Kohei ;

Morton, Laura T. ;

Sepulveda, Sean ;

Wan, Li ;

Joseph, Ricky ;

Minogue, Eleanor ;

Khatri, Ashok ;

Bardia, Aditya ;

Ellisen, Leif W. ;

Corcoran, Ryan B. ;

Hata, Aaron N. ;

Pai, Sara, I ;

Jain, Rakesh K. ;

Fukumura, Dai ;

Duda, Dan G. ;

Cobbold, Mark .

NATURE BIOTECHNOLOGY, 2020, 38 (04) :420-+

[10] SARS-CoV-2-reactive T cells in patients and healthy donors [J].

Pia, Luisanna .

NATURE REVIEWS IMMUNOLOGY, 2020, 20 (6) :353-353

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