Polymorphisms in the 5-hydroxytryptamine receptor 3B gene are associated with heroin dependence in the Chinese Han population

被引:2
作者
Yin, Fangyuan [1 ]
Ji, Yuanyuan [1 ]
Zhang, Jing [1 ]
Guo, Hao [1 ]
Huang, Xin [1 ]
Lai, Jianghua [1 ,2 ]
Wei, Shuguang [1 ,2 ]
机构
[1] Xi An Jiao Tong Univ, Coll Forens, Key Lab, Minist Publ Hlth Forens Sci, Xian, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Key Lab Environm & Genes Related Dis, Minist Educ, Xian, Shaanxi, Peoples R China
基金
美国国家科学基金会;
关键词
Heroin dependence; 5-Hydroxytryptamine receptor 3B; Single nucleotide polymorphisms; Chinese Han population; 5-HT3; RECEPTOR; DRUG-ABUSE; SEROTONIN TRANSPORTER; 3'-FLANKING REGION; MAJOR DEPRESSION; SUBSTANCE-ABUSE; ADDICTION; COCAINE; DOPAMINE; PATHWAYS;
D O I
10.1016/j.neulet.2016.10.033
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Previous studies suggested that the 5-hydroxytryptamine receptor 3B (HTR3B) is involved in heroin dependence by modulating dopamine (DA) release in the reward pathway and that the genetic polymorphisms in HTR3B play plausible role in modulating the risk of developing heroin addiction. To identify markers that contribute to the genetic susceptibility to heroin dependence, we examined the potential associations between heroin dependence and 7 single nucleotide polymorphisms (SNPs) of the HTR3B gene using multiplex SNaPshot technology in a Chinese Han population. Participants included 418 heroin dependent subjects and 422 healthy controls. The results suggested that the genotype distribution of HTR3B rs1176746 and rs1185027 were significantly different between heroin dependent subjects and healthy controls (both p = 0.004). The frequency of the GG of rs1176746 and AA of rs1185027 genotype in heroin-dependent subjects were significantly higher than that of healthy controls, while the GA of rs1176746 and AT of rs1185027 genotype distributions were much lower. Another SNP, rs10789970, showed a nominally significant p-value in the genotype distribution between heroin dependent subjects and controls (p = 0.022). These findings indicate the important role of HTR3B polymorphisms in heroin dependence among the Chinese Han population and provide valuable information for further genetic and neurobiological investigations of heroin dependence. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:123 / 129
页数:7
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