Convergent Total Synthesis of (+)-Ophiobolin A

被引：48

作者：

Tsuna, Kazuhiro ^{[1
]}

Noguchi, Naoyoshi ^{[1
]}

Nakada, Masahisa ^{[1
]}

机构：

[1] Waseda Univ, Dept Chem & Biochem, Fac Sci & Engn, Shinjuku Ku, Tokyo 1698555, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 40期

关键词：

cross-coupling; natural products; ring-closing metathesis; sesterterpenes; total synthesis; RING-CLOSING METATHESIS; NATURALLY-OCCURRING CYCLOOCTANOIDS; SILYLOXY-COPE REARRANGEMENT; OPHIOBOLANE SESTERTERPENES; CEROPLASTIN NUCLEUS; 8-MEMBERED RINGS; CEPHALONIC ACID; BUILDING-BLOCK; FACILE ROUTES; ALBOLIC ACID;

D O I：

10.1002/anie.201104447

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

At long last: The enantioselective total synthesis of the title compound, which was isolated in 1958, proceeds by a convergent approach. The assembly of the C,D-ring fragment and the A-ring fragment of the core structure is achieved by employing a Reformatsky-type reaction. The eight-membered carbocyclic B ring is efficiently constructed by a challenging ring-closing metathesis (see scheme). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9452 / 9455

页数：4

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