Natural history of primary biliary cirrhosis

被引：24

作者：

Abe, Masanori ^{[1
]}

Onji, Morikazu ^{[1
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metab, Matsuyama, Ehime 790, Japan

来源：

HEPATOLOGY RESEARCH | 2008年 / 38卷 / 07期

关键词：

natural history; primary biliary cirrhosis; symptoms;

D O I：

10.1111/j.1872-034X.2008.00351.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The natural history of primary biliary cirrhosis (PBC) has improved significantly over the last two decades. Most patients are diagnosed with asymptomatic PBC (a-PBC). The prognosis of a-PBC is usually better than that of symptomatic PBC (s-PBC). Among a-PBC patients, some remain asymptomatic, whereas others progress to s-PBC. The prognosis of s-PBC is still poor and the main cause of death in PBC is liver failure. Other complications, such as esophageal varices and hepatocellular carcinoma, also affect the prognosis of PBC patients. Ursodeoxycholic acid treatment improves the prognosis of PBC patients in the early stage. There seems to be several types of PBC progression.

引用

页码：639 / 645

页数：7

共 70 条

[21]

Hiasa Yoichi, 2003, Nihon Shokakibyo Gakkai Zasshi, V100, P1400

[22]

INOUE K, 1995, LIVER, V15, P70

[23] Autoantibodies against a 210 kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis [J].

Itoh, S ;

Ichida, T ;

Yoshida, T ;

Hayakawa, A ;

Uchida, M ;

Tashiro-Itoh, T ;

Matsuda, Y ;

Ishihara, K ;

Asakura, H .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1998, 13 (03) :257-265

[24] Four year follow up of fatigue in a geographically defined primary biliary cirrhosis patient cohort [J].

Jones, DEJ ;

Bhala, N ;

Burt, J ;

Goldblatt, J ;

Prince, M ;

Newton, JL .

GUT, 2006, 55 (04) :536-541

[25] Familial primary biliary cirrhosis reassessed: a geographically-based population study [J].

Jones, DEJ ;

Watt, FE ;

Metcalf, JV ;

Bassendine, MF ;

James, OFW .

JOURNAL OF HEPATOLOGY, 1999, 30 (03) :402-407

[26]

Jones DEJ, 1997, HEPATOLOGY, V26, P1138

[27] Medical progress: Primary biliary cirrhosis [J].

Kaplan, MM ;

Gershwin, ME .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (12) :1261-1273

[28] PORTAL HYPERTENSION IN PRIMARY BILIARY CIRRHOSIS [J].

KEW, MC ;

VARMA, RR ;

DOSSANTO.HA ;

SCHEUER, PJ ;

SHERLOCK, S .

GUT, 1971, 12 (10) :830-&

[29] Increased prevalence of antimitochondrial antibodies in first-degree relatives of patients with primary biliary cirrhosis [J].

Lazaridis, Konstantims N. ;

Juran, Brian D. ;

Boe, Gwen M. ;

Slusser, Joshua P. ;

de Andrade, Mariza ;

Homburger, Henry A. ;

Ghosh, Karthik ;

Dickson, E. Rolland ;

Lindor, Keith D. ;

Petersen, Gloria M. .

HEPATOLOGY, 2007, 46 (03) :785-792

[30] Prevalence and predictors of Esophageal varices in patients with primary biliary cirrhosis [J].

Levy, Cynthia ;

Zein, Claudia O. ;

Gomez, Justin ;

Soldevila-Pico, Consuelo ;

Firpi, Roberto ;

Morelli, Giuseppe ;

Nelson, David .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2007, 5 (07) :803-808

← 1 2 3 4 5 6 7 →