Decoding the genome beyond sequencing: The new phase of genomic research

被引：52

作者：

Heng, Henry H. Q. ^{[1
,2
,3
]}

Liu, Guo ^{[1
]}

Stevens, Joshua B. ^{[1
]}

Bremer, Steven W. ^{[1
]}

Ye, Karen J. ^{[1
]}

Abdallah, Batoul Y. ^{[1
]}

Home, Steven D. ^{[1
]}

Ye, Christine J. ^{[4
]}

机构：

[1] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA

[2] Wayne State Univ, Sch Med, Karmanos Canc Inst, Detroit, MI 48201 USA

[3] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48201 USA

[4] Wayne State Univ, Sch Med, Dept Internal Med, Detroit, MI 48201 USA

来源：

GENOMICS | 2011年 / 98卷 / 04期

关键词：

Genome theory; Genome context; Genome chaos; Genome instability; Non clonal chromosome aberrations (NCCAs); Clonal chromosome aberrations (CCAs); Genetic coding; Punctuated cancer evolution; CLONAL CHROMOSOME-ABERRATIONS; IN-SITU HYBRIDIZATION; EPIGENETIC HETEROGENEITY; EVOLUTIONARY MECHANISM; MISSING HERITABILITY; CANCER PROGRESSION; GENE-EXPRESSION; CENTRIC CONCEPT; DIMENSIONS; CHROMATIN;

D O I：

10.1016/j.ygeno.2011.05.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

While our understanding of gene-based biology has greatly improved, it is clear that the function of the genome and most diseases cannot be fully explained by genes and other regulatory elements. Genes and the genome represent distinct levels of genetic organization with their own coding systems; Genes code parts like protein and RNA, but the genome codes the structure of genetic networks, which are defined by the whole set of genes, chromosomes and their topological interactions within a cell. Accordingly, the genetic code of DNA offers limited understanding of genome functions. In this perspective, we introduce the genome theory which calls for the departure of gene-centric genomic research. To make this transition for the next phase of genomic research, it is essential to acknowledge the importance of new genome-based biological concepts and to establish new technology platforms to decode the genome beyond sequencing. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：242 / 252

页数：11

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