Rho GTPases as regulators of morphological neuroplasticity

被引：73

作者：

Auer, Maria ^{[1
]}

Hausott, Barbara ^{[1
]}

Klimaschewski, Lars ^{[1
]}

机构：

[1] Med Univ Innsbruck, Div Neuroanat, A-6020 Innsbruck, Austria

来源：

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2011年 / 193卷 / 04期

基金：

奥地利科学基金会;

关键词：

Rac; Cdc42; GEF; GAP; Axon; Dendrite; Growth cone; Branching; Sprouting; Elongation; GROWTH CONE COLLAPSE; MYELIN-ASSOCIATED GLYCOPROTEIN; ADULT SENSORY NEURONS; ENHANCES AXONAL REGENERATION; GLYCOGEN-SYNTHASE KINASE-3; SIGNALING PATHWAY; NEURITE GROWTH; MESSENGER-RNA; PC12; CELLS; NOGO-A;

D O I：

10.1016/j.aanat.2011.02.015

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

GTPases function as intracellular, bimolecular switches by adopting different conformational states in response to binding GDP or GTP. Their activation is mediated through cell-surface receptors. Rho GTPases act on several downstream effectors involved in cellular morphogenesis, cell polarity, migration and cell division. In neurons, Rho GTPases regulate various features of dendritic and axonal outgrowth during development and regeneration mainly through their effects on the cytoskeleton. This review summarizes the main functions of Rho, Rac and Cdc42 GTPases as key regulators of morphological neuroplasticity under normal and pathological conditions. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：259 / 266

页数：8

共 112 条

[41] Rho and Ras GTPases in Axon Growth, Guidance, and Branching [J].

Hall, Alan ;

Lalli, Giovanna .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2010, 2 (02) :a001818

[42] Direct interaction of Rnd1 with FRS2β regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells [J].

Harada, A ;

Katoh, H ;

Negishi, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (18) :18418-18424

[43] Sprouty2 down-regulation promotes axon growth by adult sensory neurons [J].

Hausott, Barbara ;

Vallant, Natalie ;

Auer, Maria ;

Yang, Lin ;

Dai, Fangping ;

Brand-Saberi, Beate ;

Klimaschewski, Lars .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2009, 42 (04) :328-340

[44] Mammalian Rho GTPases:: new insights into their functions from in vivo studies [J].

Heasman, Sarah J. ;

Ridley, Anne J. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (09) :690-701

[45] TARGET CONTROL OF COLLATERAL EXTENSION AND DIRECTIONAL AXON GROWTH IN THE MAMMALIAN BRAIN [J].

HEFFNER, CD ;

LUMSDEN, AGS ;

OLEARY, DDM .

SCIENCE, 1990, 247 (4939) :217-220

[46] Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury [J].

Hiraga, Akiyuki ;

Kuwabara, Satoshi ;

Doya, Hideo ;

Kanai, Kazuaki ;

Fujitani, Masashi ;

Taniguchi, Junko ;

Arai, Kimihito ;

Mori, Masahiro ;

Hattori, Takamichi ;

Yamashita, Toshihide .

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2006, 11 (03) :217-224

[47]

Huber AB, 2002, J NEUROSCI, V22, P3553

[48] Nogo-A expression in the intact and injured nervous system [J].

Hunt, D ;

Coffin, RS ;

Prinjha, RK ;

Campbell, G ;

Anderson, PN .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2003, 24 (04) :1083-1102

[49] Nogo receptor mRNA expression in intact and regenerating CNS neurons [J].

Hunt, D ;

Mason, MRJ ;

Campbell, G ;

Coffin, R ;

Anderson, PN .

MOLECULAR AND CELLULAR NEUROSCIENCE, 2002, 20 (04) :537-552

[50] Crosstalk between small GTPases and polarity proteins in cell polarization [J].

Iden, Sandra ;

Collard, John G. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (11) :846-859

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