Rho GTPases as regulators of morphological neuroplasticity

被引：71
作者：
Auer, Maria [1 ]
Hausott, Barbara [1 ]
Klimaschewski, Lars [1 ]
机构：
[1] Med Univ Innsbruck, Div Neuroanat, A-6020 Innsbruck, Austria
来源：
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2011年 / 193卷 / 04期
基金：
奥地利科学基金会;
关键词：
Rac; Cdc42; GEF; GAP; Axon; Dendrite; Growth cone; Branching; Sprouting; Elongation; GROWTH CONE COLLAPSE; MYELIN-ASSOCIATED GLYCOPROTEIN; ADULT SENSORY NEURONS; ENHANCES AXONAL REGENERATION; GLYCOGEN-SYNTHASE KINASE-3; SIGNALING PATHWAY; NEURITE GROWTH; MESSENGER-RNA; PC12; CELLS; NOGO-A;
D O I：
10.1016/j.aanat.2011.02.015
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
GTPases function as intracellular, bimolecular switches by adopting different conformational states in response to binding GDP or GTP. Their activation is mediated through cell-surface receptors. Rho GTPases act on several downstream effectors involved in cellular morphogenesis, cell polarity, migration and cell division. In neurons, Rho GTPases regulate various features of dendritic and axonal outgrowth during development and regeneration mainly through their effects on the cytoskeleton. This review summarizes the main functions of Rho, Rac and Cdc42 GTPases as key regulators of morphological neuroplasticity under normal and pathological conditions. (C) 2011 Elsevier GmbH. All rights reserved.
引用
收藏
页码：259 / 266
页数：8
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